Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings
Abstract Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). Different microRNAs (miRNAs) involve in several steps of this process. Indeed, miRNAs are small single-stranded non-coding...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03504-3 |
| _version_ | 1797577779561103360 |
|---|---|
| author | Seyed Mahdi Nassiri Neda Ahmadi Afshar Parsa Almasi |
| author_facet | Seyed Mahdi Nassiri Neda Ahmadi Afshar Parsa Almasi |
| author_sort | Seyed Mahdi Nassiri |
| collection | DOAJ |
| description | Abstract Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). Different microRNAs (miRNAs) involve in several steps of this process. Indeed, miRNAs are small single-stranded non-coding RNA molecules, which control gene expression by translational inhibition and mRNA destabilization. Previous studies have revealed that increased or decreased expression of some of these miRNAs by targeting several proto-oncogenes could inhibit or stimulate the myeloid and erythroid lineage commitment, proliferation, and differentiation. During the last decades, the development of molecular and bioinformatics techniques has led to a comprehensive understanding of the role of various miRNAs in hematopoiesis. The critical roles of miRNAs in cell processes such as the cell cycle, apoptosis, and differentiation have been confirmed as well. However, the main contribution of some miRNAs is still unclear. Therefore, it seems undeniable that future studies are required to focus on miRNA activities during various hematopoietic stages and hematological malignancy. |
| first_indexed | 2024-03-10T22:12:51Z |
| format | Article |
| id | doaj.art-e42f5632908f49f19625793147c1cbc3 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-10T22:12:51Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-e42f5632908f49f19625793147c1cbc32023-11-19T12:33:47ZengBMCStem Cell Research & Therapy1757-65122023-10-0114112610.1186/s13287-023-03504-3Insight into microRNAs’ involvement in hematopoiesis: current standing point of findingsSeyed Mahdi Nassiri0Neda Ahmadi Afshar1Parsa Almasi2Department of Clinical Pathology, Faculty of Veterinary Medicine, University of TehranDepartment of Clinical Pathology, Faculty of Veterinary Medicine, University of TehranDepartment of Clinical Pathology, Faculty of Veterinary Medicine, University of TehranAbstract Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). Different microRNAs (miRNAs) involve in several steps of this process. Indeed, miRNAs are small single-stranded non-coding RNA molecules, which control gene expression by translational inhibition and mRNA destabilization. Previous studies have revealed that increased or decreased expression of some of these miRNAs by targeting several proto-oncogenes could inhibit or stimulate the myeloid and erythroid lineage commitment, proliferation, and differentiation. During the last decades, the development of molecular and bioinformatics techniques has led to a comprehensive understanding of the role of various miRNAs in hematopoiesis. The critical roles of miRNAs in cell processes such as the cell cycle, apoptosis, and differentiation have been confirmed as well. However, the main contribution of some miRNAs is still unclear. Therefore, it seems undeniable that future studies are required to focus on miRNA activities during various hematopoietic stages and hematological malignancy.https://doi.org/10.1186/s13287-023-03504-3DifferentiationMyelopoiesisHematopoiesismiRNA |
| spellingShingle | Seyed Mahdi Nassiri Neda Ahmadi Afshar Parsa Almasi Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings Stem Cell Research & Therapy Differentiation Myelopoiesis Hematopoiesis miRNA |
| title | Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings |
| title_full | Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings |
| title_fullStr | Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings |
| title_full_unstemmed | Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings |
| title_short | Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings |
| title_sort | insight into micrornas involvement in hematopoiesis current standing point of findings |
| topic | Differentiation Myelopoiesis Hematopoiesis miRNA |
| url | https://doi.org/10.1186/s13287-023-03504-3 |
| work_keys_str_mv | AT seyedmahdinassiri insightintomicrornasinvolvementinhematopoiesiscurrentstandingpointoffindings AT nedaahmadiafshar insightintomicrornasinvolvementinhematopoiesiscurrentstandingpointoffindings AT parsaalmasi insightintomicrornasinvolvementinhematopoiesiscurrentstandingpointoffindings |