The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea
Purpose The goal of this study is to investigate the effects of androgen deprivation therapy (ADT) on total prostate volume and lower urinary tract symptoms (LUTS). Methods Between January 2007 and June 2014, 110 patients who received androgen deprivation treatment were enrolled in this retrospectiv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Continence Society
2016-12-01
|
| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-1632628-314.pdf |
| _version_ | 1819130970318569472 |
|---|---|
| author | Hoon Choi Hong Chung Jae Young Park Jeong Gu Lee Jae Hyun Bae |
| author_facet | Hoon Choi Hong Chung Jae Young Park Jeong Gu Lee Jae Hyun Bae |
| author_sort | Hoon Choi |
| collection | DOAJ |
| description | Purpose The goal of this study is to investigate the effects of androgen deprivation therapy (ADT) on total prostate volume and lower urinary tract symptoms (LUTS). Methods Between January 2007 and June 2014, 110 patients who received androgen deprivation treatment were enrolled in this retrospective study. Clinical parameters and urodynamic parameters along with changes at follow-up were analyzed. Factors such as reduction in prostate volume, changes in LUTS, and prostate volume tertiles were compared 1 year after ADT. Results After ADT, the total International Prostate Symptom Score (IPSS) score decreased from 17.45 to 12.21 and the IPSS voiding subscore decreased from 9.16 to 6.24. Maximal uroflow rate increased from 8.62 to 11.50 mL/sec and residual urine also reduced significantly by 29.34 mL. Change in prostate size was more prominent (–51.14%) in the patients with less than 1 year of ADT (n=21) than those who had more than 1 year of treatment (n=89, –44.12%). The decrease in the IPSS voiding subscore was greater within 1 year of ADT than after 1 year of treatment (–4.10 vs. –2.65). The differences were more significant in the 30–50 g group (n=59) and >50 g group (n=11) than the <30 g group (n=40) of the IPSS voiding subscore improvement (–3.76 , –4.91 vs. –2.10), and maximal uroflow rate improvement (2.78, 2.90 vs 1.49). Conclusion ADT resulted in statistically significant clinical improvement in terms of prostate volume, urodynamic parameters, and LUTS for patients with prostate cancer when analyzed by ADT duration and prostate volume. |
| first_indexed | 2024-12-22T09:08:04Z |
| format | Article |
| id | doaj.art-e431319f955842a2a7a6f34bc222fc1c |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-22T09:08:04Z |
| publishDate | 2016-12-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-e431319f955842a2a7a6f34bc222fc1c2022-12-21T18:31:32ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312016-12-0120434234810.5213/inj.1632628.314637The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in KoreaHoon Choi0Hong Chung1Jae Young Park2Jeong Gu Lee3Jae Hyun Bae4 Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea Department of Urology, Konkuk University Hospital, Chungju, Korea Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, KoreaPurpose The goal of this study is to investigate the effects of androgen deprivation therapy (ADT) on total prostate volume and lower urinary tract symptoms (LUTS). Methods Between January 2007 and June 2014, 110 patients who received androgen deprivation treatment were enrolled in this retrospective study. Clinical parameters and urodynamic parameters along with changes at follow-up were analyzed. Factors such as reduction in prostate volume, changes in LUTS, and prostate volume tertiles were compared 1 year after ADT. Results After ADT, the total International Prostate Symptom Score (IPSS) score decreased from 17.45 to 12.21 and the IPSS voiding subscore decreased from 9.16 to 6.24. Maximal uroflow rate increased from 8.62 to 11.50 mL/sec and residual urine also reduced significantly by 29.34 mL. Change in prostate size was more prominent (–51.14%) in the patients with less than 1 year of ADT (n=21) than those who had more than 1 year of treatment (n=89, –44.12%). The decrease in the IPSS voiding subscore was greater within 1 year of ADT than after 1 year of treatment (–4.10 vs. –2.65). The differences were more significant in the 30–50 g group (n=59) and >50 g group (n=11) than the <30 g group (n=40) of the IPSS voiding subscore improvement (–3.76 , –4.91 vs. –2.10), and maximal uroflow rate improvement (2.78, 2.90 vs 1.49). Conclusion ADT resulted in statistically significant clinical improvement in terms of prostate volume, urodynamic parameters, and LUTS for patients with prostate cancer when analyzed by ADT duration and prostate volume.http://www.einj.org/upload/pdf/inj-1632628-314.pdfAndrogen Deprivation TherapyProstate NeoplasmsProstate Volume |
| spellingShingle | Hoon Choi Hong Chung Jae Young Park Jeong Gu Lee Jae Hyun Bae The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea International Neurourology Journal Androgen Deprivation Therapy Prostate Neoplasms Prostate Volume |
| title | The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea |
| title_full | The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea |
| title_fullStr | The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea |
| title_full_unstemmed | The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea |
| title_short | The Influence of Androgen Deprivation Therapy on Prostate Size and Voiding Symptoms in Prostate Cancer Patients in Korea |
| title_sort | influence of androgen deprivation therapy on prostate size and voiding symptoms in prostate cancer patients in korea |
| topic | Androgen Deprivation Therapy Prostate Neoplasms Prostate Volume |
| url | http://www.einj.org/upload/pdf/inj-1632628-314.pdf |
| work_keys_str_mv | AT hoonchoi theinfluenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT hongchung theinfluenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jaeyoungpark theinfluenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jeonggulee theinfluenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jaehyunbae theinfluenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT hoonchoi influenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT hongchung influenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jaeyoungpark influenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jeonggulee influenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea AT jaehyunbae influenceofandrogendeprivationtherapyonprostatesizeandvoidingsymptomsinprostatecancerpatientsinkorea |