Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity
Abstract Background To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on the cardiac renin angiotensin system (RAS), and to investigate the cardiac protection of an angiotensin receptor blocker (ARB)telmisartan (TERT) against CIH. Methods 32 healthy mal...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-018-0875-4 |
| _version_ | 1818341557356462080 |
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| author | Wanyu Wang Ailing Song Yiming Zeng Xiaoyang Chen Yixiang Zhang Yonghong Shi Yihua Lin Wen Luo |
| author_facet | Wanyu Wang Ailing Song Yiming Zeng Xiaoyang Chen Yixiang Zhang Yonghong Shi Yihua Lin Wen Luo |
| author_sort | Wanyu Wang |
| collection | DOAJ |
| description | Abstract Background To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on the cardiac renin angiotensin system (RAS), and to investigate the cardiac protection of an angiotensin receptor blocker (ARB)telmisartan (TERT) against CIH. Methods 32 healthy male C57B6J mice were randomly divided into CIH, ARB, blank and air control groups. CIH lasted for 12 weeks. Cardiac angiotensin converting enzyme (ACE), angiotensin converting enzyme 2 (ACE 2) and angiotensin II (Ang II) were evaluated by immunohistochemistry. Myocardial apoptosis were assessed by TUNEL assay and myocardial cell ultrastructure were observed under transmission electron microscope. Results Cardiac ACE expression was higher in the CIH group than in blank and air control groups, which was decreased with TERT treatment. TERT treatment elevated the expression of cardiac ACE 2 and Ang II compared with CIH group. Myocardial cell and capillary endothelial cell apoptosis, mitochondrial injury were most severe in CIH groups, which were mitigated with TERT treatment. Conclusions CIH changes the expression of cardiac ACE, ACE2 and Ang II, which may cause myocardial damage. TERT protects mice from CIH-linked cardiac damage via modulating the activity of RAS in the hearts. |
| first_indexed | 2024-12-13T16:00:41Z |
| format | Article |
| id | doaj.art-e431787a0d5049099df8463bc5673224 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-13T16:00:41Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e431787a0d5049099df8463bc56732242022-12-21T23:39:11ZengBMCBMC Cardiovascular Disorders1471-22612018-07-011811910.1186/s12872-018-0875-4Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activityWanyu Wang0Ailing Song1Yiming Zeng2Xiaoyang Chen3Yixiang Zhang4Yonghong Shi5Yihua Lin6Wen Luo7Pneumology Department of the First Affiliated Hospital of XiaMen University, The first clinical medical college of Fujian Medical University Teaching hospital of Fujian Medical UniversityPneumology Department of Wuxi Branch of Rijin Hospital affiliated to Shanghai jiaotong university medical collegeDepartment of Pulmonary and Critical Care Medicine of the Second Affiliated Hospital of Fujian Medical University, Sleep and Breathing Disorders Research Institute of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine of the Second Affiliated Hospital of Fujian Medical University, Sleep and Breathing Disorders Research Institute of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine of the Second Affiliated Hospital of Fujian Medical University, Sleep and Breathing Disorders Research Institute of Fujian Medical UniversityPneumology Department of the First Affiliated Hospital of XiaMen University, The first clinical medical college of Fujian Medical University Teaching hospital of Fujian Medical UniversityPneumology Department of the First Affiliated Hospital of XiaMen University, The first clinical medical college of Fujian Medical University Teaching hospital of Fujian Medical UniversityPneumology Department of the First Affiliated Hospital of XiaMen University, The first clinical medical college of Fujian Medical University Teaching hospital of Fujian Medical UniversityAbstract Background To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on the cardiac renin angiotensin system (RAS), and to investigate the cardiac protection of an angiotensin receptor blocker (ARB)telmisartan (TERT) against CIH. Methods 32 healthy male C57B6J mice were randomly divided into CIH, ARB, blank and air control groups. CIH lasted for 12 weeks. Cardiac angiotensin converting enzyme (ACE), angiotensin converting enzyme 2 (ACE 2) and angiotensin II (Ang II) were evaluated by immunohistochemistry. Myocardial apoptosis were assessed by TUNEL assay and myocardial cell ultrastructure were observed under transmission electron microscope. Results Cardiac ACE expression was higher in the CIH group than in blank and air control groups, which was decreased with TERT treatment. TERT treatment elevated the expression of cardiac ACE 2 and Ang II compared with CIH group. Myocardial cell and capillary endothelial cell apoptosis, mitochondrial injury were most severe in CIH groups, which were mitigated with TERT treatment. Conclusions CIH changes the expression of cardiac ACE, ACE2 and Ang II, which may cause myocardial damage. TERT protects mice from CIH-linked cardiac damage via modulating the activity of RAS in the hearts.http://link.springer.com/article/10.1186/s12872-018-0875-4Chronic intermittent hypoxiaSleep apnea syndromesTelmisartinACEACE 2Ang II |
| spellingShingle | Wanyu Wang Ailing Song Yiming Zeng Xiaoyang Chen Yixiang Zhang Yonghong Shi Yihua Lin Wen Luo Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity BMC Cardiovascular Disorders Chronic intermittent hypoxia Sleep apnea syndromes Telmisartin ACE ACE 2 Ang II |
| title | Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity |
| title_full | Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity |
| title_fullStr | Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity |
| title_full_unstemmed | Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity |
| title_short | Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity |
| title_sort | telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin angiotensin system activity |
| topic | Chronic intermittent hypoxia Sleep apnea syndromes Telmisartin ACE ACE 2 Ang II |
| url | http://link.springer.com/article/10.1186/s12872-018-0875-4 |
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