Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle
Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in muscle cells in response to lipotoxcity.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29363-9 |
| _version_ | 1811273025555791872 |
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| author | Ben D. McNally Dean F. Ashley Lea Hänschke Hélène N. Daou Nicole T. Watt Steven A. Murfitt Amanda D. V. MacCannell Anna Whitehead T. Scott Bowen Francis W. B. Sanders Michele Vacca Klaus K. Witte Graeme R. Davies Reinhard Bauer Julian L. Griffin Lee D. Roberts |
| author_facet | Ben D. McNally Dean F. Ashley Lea Hänschke Hélène N. Daou Nicole T. Watt Steven A. Murfitt Amanda D. V. MacCannell Anna Whitehead T. Scott Bowen Francis W. B. Sanders Michele Vacca Klaus K. Witte Graeme R. Davies Reinhard Bauer Julian L. Griffin Lee D. Roberts |
| author_sort | Ben D. McNally |
| collection | DOAJ |
| description | Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in muscle cells in response to lipotoxcity. |
| first_indexed | 2024-04-12T22:50:46Z |
| format | Article |
| id | doaj.art-e431ba3360bc41d78c30c04a825835be |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T22:50:46Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e431ba3360bc41d78c30c04a825835be2022-12-22T03:13:22ZengNature PortfolioNature Communications2041-17232022-04-0113111710.1038/s41467-022-29363-9Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscleBen D. McNally0Dean F. Ashley1Lea Hänschke2Hélène N. Daou3Nicole T. Watt4Steven A. Murfitt5Amanda D. V. MacCannell6Anna Whitehead7T. Scott Bowen8Francis W. B. Sanders9Michele Vacca10Klaus K. Witte11Graeme R. Davies12Reinhard Bauer13Julian L. Griffin14Lee D. Roberts15Department of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeLife & Medical Sciences Institute (LIMES) Development, Genetics & Molecular Physiology Unit, University of BonnSchool of Medicine, University of LeedsSchool of Medicine, University of LeedsDepartment of Biochemistry, University of CambridgeSchool of Medicine, University of LeedsSchool of Medicine, University of LeedsFaculty of Biological Sciences, University of LeedsDepartment of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeSchool of Medicine, University of LeedsBioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZenecaLife & Medical Sciences Institute (LIMES) Development, Genetics & Molecular Physiology Unit, University of BonnDepartment of Biochemistry, University of CambridgeSchool of Medicine, University of LeedsEndoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in muscle cells in response to lipotoxcity.https://doi.org/10.1038/s41467-022-29363-9 |
| spellingShingle | Ben D. McNally Dean F. Ashley Lea Hänschke Hélène N. Daou Nicole T. Watt Steven A. Murfitt Amanda D. V. MacCannell Anna Whitehead T. Scott Bowen Francis W. B. Sanders Michele Vacca Klaus K. Witte Graeme R. Davies Reinhard Bauer Julian L. Griffin Lee D. Roberts Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle Nature Communications |
| title | Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| title_full | Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| title_fullStr | Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| title_full_unstemmed | Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| title_short | Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| title_sort | long chain ceramides are cell non autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle |
| url | https://doi.org/10.1038/s41467-022-29363-9 |
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