Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring
BackgroundMaternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective cohort study examined associations between maternal b...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346900/full |
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| author | Amaraporn Rerkasem Jaz Lyons-Reid Sirianong Namwongprom Suthathip Wongsrithep Ampica Mangklabruks Kochaphan Phirom Kittipan Rerkasem Kittipan Rerkasem José G. B. Derraik José G. B. Derraik José G. B. Derraik |
| author_facet | Amaraporn Rerkasem Jaz Lyons-Reid Sirianong Namwongprom Suthathip Wongsrithep Ampica Mangklabruks Kochaphan Phirom Kittipan Rerkasem Kittipan Rerkasem José G. B. Derraik José G. B. Derraik José G. B. Derraik |
| author_sort | Amaraporn Rerkasem |
| collection | DOAJ |
| description | BackgroundMaternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective cohort study examined associations between maternal body mass index (BMI) during pregnancy and body composition in the young adult offspring.MethodsParticipants were the offspring from a birth cohort in Chiang Mai (Thailand). Maternal BMI was assessed at the first antenatal clinic visit (≤24 weeks of gestation) in 1989–1990. In 2010–2011, we followed up the offspring at approximately 20 years of age, assessing their body composition using whole-body dual-energy X-ray absorptiometry (DXA) scans. Associations between maternal BMI and offspring body composition were explored using unadjusted and adjusted analyses.ResultsWe assessed 391 young adults (55% were females). Higher maternal BMI was associated with increased offspring fat mass and lean mass. In adjusted analyses, offspring of mothers with overweight/obesity exhibited total body fat percentages 1.5 (95% CI 0.1, 2.9; p = 0.032) and 2.3 (95% CI 0.2, 4.5; p = 0.036) percentage points higher than offspring of normal-weight and underweight mothers, respectively. Fat mass index was similarly higher: 0.9 kg/m2 (95% CI 0.3, 1.5 kg/m2; p = 0.002) and 1.4 kg/m2 (95% CI 0.5, 2.3 kg/m2; p = 0.002), respectively. However, no differences in visceral adiposity were detected.ConclusionHigher maternal BMI during pregnancy was associated with increased adiposity in young adult offspring. Our findings suggest that the cross-generational transmission of maternal obesity-related traits is associated with increased offspring adiposity in the long term. |
| first_indexed | 2024-04-25T00:10:40Z |
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| issn | 2296-2565 |
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| spelling | doaj.art-e431ffccf11c499399e5ef28ca40a7952024-03-13T15:16:25ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-03-011210.3389/fpubh.2024.13469001346900Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspringAmaraporn Rerkasem0Jaz Lyons-Reid1Sirianong Namwongprom2Suthathip Wongsrithep3Ampica Mangklabruks4Kochaphan Phirom5Kittipan Rerkasem6Kittipan Rerkasem7José G. B. Derraik8José G. B. Derraik9José G. B. Derraik10Environmental-Occupational Health Sciences and Non-Communicable Diseases Research Group, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, ThailandLiggins Institute, University of Auckland, Auckland, New ZealandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandEnvironmental-Occupational Health Sciences and Non-Communicable Diseases Research Group, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandEnvironmental-Occupational Health Sciences and Non-Communicable Diseases Research Group, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, ThailandEnvironmental-Occupational Health Sciences and Non-Communicable Diseases Research Group, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, ThailandDepartment of Surgery, Faculty of Medicine, Clinical Surgical Research Center, Chiang Mai University, Chiang Mai, ThailandEnvironmental-Occupational Health Sciences and Non-Communicable Diseases Research Group, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, ThailandDepartment of Women’s and Children’s Health, Uppsala University, Uppsala, SwedenDepartment of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New ZealandBackgroundMaternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective cohort study examined associations between maternal body mass index (BMI) during pregnancy and body composition in the young adult offspring.MethodsParticipants were the offspring from a birth cohort in Chiang Mai (Thailand). Maternal BMI was assessed at the first antenatal clinic visit (≤24 weeks of gestation) in 1989–1990. In 2010–2011, we followed up the offspring at approximately 20 years of age, assessing their body composition using whole-body dual-energy X-ray absorptiometry (DXA) scans. Associations between maternal BMI and offspring body composition were explored using unadjusted and adjusted analyses.ResultsWe assessed 391 young adults (55% were females). Higher maternal BMI was associated with increased offspring fat mass and lean mass. In adjusted analyses, offspring of mothers with overweight/obesity exhibited total body fat percentages 1.5 (95% CI 0.1, 2.9; p = 0.032) and 2.3 (95% CI 0.2, 4.5; p = 0.036) percentage points higher than offspring of normal-weight and underweight mothers, respectively. Fat mass index was similarly higher: 0.9 kg/m2 (95% CI 0.3, 1.5 kg/m2; p = 0.002) and 1.4 kg/m2 (95% CI 0.5, 2.3 kg/m2; p = 0.002), respectively. However, no differences in visceral adiposity were detected.ConclusionHigher maternal BMI during pregnancy was associated with increased adiposity in young adult offspring. Our findings suggest that the cross-generational transmission of maternal obesity-related traits is associated with increased offspring adiposity in the long term.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346900/fulladipositybirth cohortbody fatdual-energy X-ray absorptiometryDXAfollow-up |
| spellingShingle | Amaraporn Rerkasem Jaz Lyons-Reid Sirianong Namwongprom Suthathip Wongsrithep Ampica Mangklabruks Kochaphan Phirom Kittipan Rerkasem Kittipan Rerkasem José G. B. Derraik José G. B. Derraik José G. B. Derraik Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring Frontiers in Public Health adiposity birth cohort body fat dual-energy X-ray absorptiometry DXA follow-up |
| title | Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring |
| title_full | Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring |
| title_fullStr | Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring |
| title_full_unstemmed | Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring |
| title_short | Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring |
| title_sort | associations between maternal overweight obesity during pregnancy and body composition in young adult offspring |
| topic | adiposity birth cohort body fat dual-energy X-ray absorptiometry DXA follow-up |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346900/full |
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