Maternal high-fat diet consumption impairs exercise performance in offspring
The aim of the present study was to scrutinise the influence of maternal high-fat diet (mHFD) consumption during gestation and lactation on exercise performance and energy metabolism in male mouse offspring. Female C3H/HeJ mice were fed either a semi-synthetic high-fat diet (HFD; 40 % energy from fa...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2014-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S204867901400055X/type/journal_article |
| _version_ | 1811156023129407488 |
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| author | Isabel Walter Susanne Klaus |
| author_facet | Isabel Walter Susanne Klaus |
| author_sort | Isabel Walter |
| collection | DOAJ |
| description | The aim of the present study was to scrutinise the influence of maternal high-fat diet (mHFD) consumption during gestation and lactation on exercise performance and energy metabolism in male mouse offspring. Female C3H/HeJ mice were fed either a semi-synthetic high-fat diet (HFD; 40 % energy from fat) or a low-fat diet (LFD; 10 % energy from fat) throughout gestation and lactation. After weaning, male offspring of both groups received the LFD. At the age of 7·5 weeks half of the maternal LFD (n 20) and the mHFD (n 21) groups were given access to a running wheel for 28 d as a voluntary exercise training opportunity. We show that mHFD consumption led to a significantly reduced exercise performance (P < 0·05) and training efficiency (P < 0·05) in male offspring. There were no effects of maternal diet on offspring body weight. Lipid and glucose metabolism was disturbed in mHFD offspring, with altered regulation of cluster of differentiation 36 (CD36) (P < 0·001), fatty acid synthase (P < 0·05) and GLUT1 (P < 0·05) gene expression in skeletal muscle. In conclusion, maternal consumption of a HFD is linked to decreased exercise performance and training efficiency in the offspring. We speculate that this may be due to insufficient muscle energy supply during prolonged exercise training. Further, this compromised exercise performance might increase the risk of obesity development in adult life. |
| first_indexed | 2024-04-10T04:44:31Z |
| format | Article |
| id | doaj.art-e433824b7b704605948da55877f43931 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:31Z |
| publishDate | 2014-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-e433824b7b704605948da55877f439312023-03-09T12:38:43ZengCambridge University PressJournal of Nutritional Science2048-67902014-01-01310.1017/jns.2014.55Maternal high-fat diet consumption impairs exercise performance in offspringIsabel Walter0Susanne Klaus1Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Arthur Scheunert Allee 114–116, 14558 Nuthetal, Potsdam-Rehbruecke, GermanyGroup of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Arthur Scheunert Allee 114–116, 14558 Nuthetal, Potsdam-Rehbruecke, GermanyThe aim of the present study was to scrutinise the influence of maternal high-fat diet (mHFD) consumption during gestation and lactation on exercise performance and energy metabolism in male mouse offspring. Female C3H/HeJ mice were fed either a semi-synthetic high-fat diet (HFD; 40 % energy from fat) or a low-fat diet (LFD; 10 % energy from fat) throughout gestation and lactation. After weaning, male offspring of both groups received the LFD. At the age of 7·5 weeks half of the maternal LFD (n 20) and the mHFD (n 21) groups were given access to a running wheel for 28 d as a voluntary exercise training opportunity. We show that mHFD consumption led to a significantly reduced exercise performance (P < 0·05) and training efficiency (P < 0·05) in male offspring. There were no effects of maternal diet on offspring body weight. Lipid and glucose metabolism was disturbed in mHFD offspring, with altered regulation of cluster of differentiation 36 (CD36) (P < 0·001), fatty acid synthase (P < 0·05) and GLUT1 (P < 0·05) gene expression in skeletal muscle. In conclusion, maternal consumption of a HFD is linked to decreased exercise performance and training efficiency in the offspring. We speculate that this may be due to insufficient muscle energy supply during prolonged exercise training. Further, this compromised exercise performance might increase the risk of obesity development in adult life.https://www.cambridge.org/core/product/identifier/S204867901400055X/type/journal_articleHigh-fat dietOffspringTrainingSkeletal muscle |
| spellingShingle | Isabel Walter Susanne Klaus Maternal high-fat diet consumption impairs exercise performance in offspring Journal of Nutritional Science High-fat diet Offspring Training Skeletal muscle |
| title | Maternal high-fat diet consumption impairs exercise performance in offspring |
| title_full | Maternal high-fat diet consumption impairs exercise performance in offspring |
| title_fullStr | Maternal high-fat diet consumption impairs exercise performance in offspring |
| title_full_unstemmed | Maternal high-fat diet consumption impairs exercise performance in offspring |
| title_short | Maternal high-fat diet consumption impairs exercise performance in offspring |
| title_sort | maternal high fat diet consumption impairs exercise performance in offspring |
| topic | High-fat diet Offspring Training Skeletal muscle |
| url | https://www.cambridge.org/core/product/identifier/S204867901400055X/type/journal_article |
| work_keys_str_mv | AT isabelwalter maternalhighfatdietconsumptionimpairsexerciseperformanceinoffspring AT susanneklaus maternalhighfatdietconsumptionimpairsexerciseperformanceinoffspring |