Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response
Background Capparis decidua (Forssk.) Edgew is reported to be practiced in the traditional system of medicine for the management of various immunological pathologies. Purpose The current study was designed to evaluate the modulatory effects of C decidua on different immune responses. Research Design...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-08-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258221123672 |
| _version_ | 1811337858426863616 |
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| author | Hafiz Muhammad Farhan Rasheed Qaiser Jabeen |
| author_facet | Hafiz Muhammad Farhan Rasheed Qaiser Jabeen |
| author_sort | Hafiz Muhammad Farhan Rasheed |
| collection | DOAJ |
| description | Background Capparis decidua (Forssk.) Edgew is reported to be practiced in the traditional system of medicine for the management of various immunological pathologies. Purpose The current study was designed to evaluate the modulatory effects of C decidua on different immune responses. Research Design C decidua was extracted in 70% methanol and the crude extract (Cd.Cr) was analyzed by FTIR and GCMS. In vivo models were employed to assess the actions of Cd.Cr on cyclophosphamide-induced myelosuppression, innate and adaptive immune responses. Results GCMS and FTIR analysis indicated the presence of flavonoids, phenols, terpenoids and lipids. Cd.Cr evoked a significant and dose-dependent increase in percent neutrophil adhesion (15.97 ± .81, 27.47 ± .79 and 38.35 ± 1.08) and the phagocytic index (3.1 ± .04, 3.96 ± .06 and 5.28 ± .13) at the doses of 30, 100 and 300 mg/kg. Cd.Cr also potentiated haemagglutinating antibody titre, immunoglobulins and cytokines (interferon-γ and interleukin-2) production for 4 weeks, after exposure to sheep erythrocytes, and delayed type hypersensitivity reaction significantly ( P < .05). The restoration of hematological profile and antioxidant enzyme activities, by Cd.Cr, indicated the prevention of cyclophosphamide-induced myelosuppression and oxidative stress. Conclusions The findings of this study suggest that C decidua holds immunomodulatory activity by thus possesses therapeutic potential for the management of immunological diseases. |
| first_indexed | 2024-04-13T18:01:09Z |
| format | Article |
| id | doaj.art-e434559abb1848e6957940b4d07d3df8 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-04-13T18:01:09Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-e434559abb1848e6957940b4d07d3df82022-12-22T02:36:14ZengSAGE PublishingDose-Response1559-32582022-08-012010.1177/15593258221123672Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune ResponseHafiz Muhammad Farhan RasheedQaiser JabeenBackground Capparis decidua (Forssk.) Edgew is reported to be practiced in the traditional system of medicine for the management of various immunological pathologies. Purpose The current study was designed to evaluate the modulatory effects of C decidua on different immune responses. Research Design C decidua was extracted in 70% methanol and the crude extract (Cd.Cr) was analyzed by FTIR and GCMS. In vivo models were employed to assess the actions of Cd.Cr on cyclophosphamide-induced myelosuppression, innate and adaptive immune responses. Results GCMS and FTIR analysis indicated the presence of flavonoids, phenols, terpenoids and lipids. Cd.Cr evoked a significant and dose-dependent increase in percent neutrophil adhesion (15.97 ± .81, 27.47 ± .79 and 38.35 ± 1.08) and the phagocytic index (3.1 ± .04, 3.96 ± .06 and 5.28 ± .13) at the doses of 30, 100 and 300 mg/kg. Cd.Cr also potentiated haemagglutinating antibody titre, immunoglobulins and cytokines (interferon-γ and interleukin-2) production for 4 weeks, after exposure to sheep erythrocytes, and delayed type hypersensitivity reaction significantly ( P < .05). The restoration of hematological profile and antioxidant enzyme activities, by Cd.Cr, indicated the prevention of cyclophosphamide-induced myelosuppression and oxidative stress. Conclusions The findings of this study suggest that C decidua holds immunomodulatory activity by thus possesses therapeutic potential for the management of immunological diseases.https://doi.org/10.1177/15593258221123672 |
| spellingShingle | Hafiz Muhammad Farhan Rasheed Qaiser Jabeen Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response Dose-Response |
| title | Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response |
| title_full | Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response |
| title_fullStr | Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response |
| title_full_unstemmed | Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response |
| title_short | Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response |
| title_sort | pharmacological role of forssk edgew in preventing cyclophosphamide induced myelosuppression and modulating innate and adaptive immune response |
| url | https://doi.org/10.1177/15593258221123672 |
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