TERT—Regulation and Roles in Cancer Formation
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, T...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.589929/full |
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| author | Marta Dratwa Barbara Wysoczańska Piotr Łacina Tomasz Kubik Katarzyna Bogunia-Kubik |
| author_facet | Marta Dratwa Barbara Wysoczańska Piotr Łacina Tomasz Kubik Katarzyna Bogunia-Kubik |
| author_sort | Marta Dratwa |
| collection | DOAJ |
| description | Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. All of them are cancer specific at tissue histotype and at single cell level. TERT expression is regulated in tumors via multiple genetic and epigenetic alterations which affect telomerase activity. Telomerase activity via TERT expression has an impact on telomere length and can be a useful marker in diagnosis and prognosis of various cancers and a new therapy approach. In this review we want to highlight the main roles of TERT in different mechanisms of cancer development and regulation. |
| first_indexed | 2024-12-17T13:10:51Z |
| format | Article |
| id | doaj.art-e435fc00fba44b4699d99b45ccac4123 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T13:10:51Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e435fc00fba44b4699d99b45ccac41232022-12-21T21:47:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.589929589929TERT—Regulation and Roles in Cancer FormationMarta Dratwa0Barbara Wysoczańska1Piotr Łacina2Tomasz Kubik3Katarzyna Bogunia-Kubik4Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandDepartment of Computer Engineering, Faculty of Electronics, Wrocław University of Science and Technology, Wroclaw, PolandLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandTelomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. All of them are cancer specific at tissue histotype and at single cell level. TERT expression is regulated in tumors via multiple genetic and epigenetic alterations which affect telomerase activity. Telomerase activity via TERT expression has an impact on telomere length and can be a useful marker in diagnosis and prognosis of various cancers and a new therapy approach. In this review we want to highlight the main roles of TERT in different mechanisms of cancer development and regulation.https://www.frontiersin.org/articles/10.3389/fimmu.2020.589929/fulltelomerase reverse transcriptasecancer progressionTERTp mutationstelomere maintenance mechanismsTERT structural variantsTERT epigenetic alterations |
| spellingShingle | Marta Dratwa Barbara Wysoczańska Piotr Łacina Tomasz Kubik Katarzyna Bogunia-Kubik TERT—Regulation and Roles in Cancer Formation Frontiers in Immunology telomerase reverse transcriptase cancer progression TERTp mutations telomere maintenance mechanisms TERT structural variants TERT epigenetic alterations |
| title | TERT—Regulation and Roles in Cancer Formation |
| title_full | TERT—Regulation and Roles in Cancer Formation |
| title_fullStr | TERT—Regulation and Roles in Cancer Formation |
| title_full_unstemmed | TERT—Regulation and Roles in Cancer Formation |
| title_short | TERT—Regulation and Roles in Cancer Formation |
| title_sort | tert regulation and roles in cancer formation |
| topic | telomerase reverse transcriptase cancer progression TERTp mutations telomere maintenance mechanisms TERT structural variants TERT epigenetic alterations |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.589929/full |
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