TERT—Regulation and Roles in Cancer Formation

TERT—Regulation and Roles in Cancer Formation

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, T...

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Bibliographic Details
Main Authors: Marta Dratwa, Barbara Wysoczańska, Piotr Łacina, Tomasz Kubik, Katarzyna Bogunia-Kubik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
telomerase reverse transcriptase
cancer progression
TERTp mutations
telomere maintenance mechanisms
TERT structural variants
TERT epigenetic alterations
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.589929/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.589929/full

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