The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Molecular Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13024-021-00496-7 |
| _version_ | 1818754122384408576 |
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| author | Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta |
| author_facet | Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta |
| author_sort | Hannah Walgrave |
| collection | DOAJ |
| description | Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation of their regulatory potential in healthy and diseased brain. However, systematic interrogation of putative therapeutic or toxic effects of microRNAs in (models of) Alzheimer’s disease is currently missing and fundamental research findings are yet to be translated into clinical applications. Here, we review the literature to summarize the knowledge on microRNA regulation in Alzheimer’s pathophysiology and to critically discuss whether and to what extent these increasing insights can be exploited for the development of microRNA-based therapeutics in the clinic. |
| first_indexed | 2024-12-18T05:18:14Z |
| format | Article |
| id | doaj.art-e43a11d9d7444dbc9f5e8a4b95efafba |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-18T05:18:14Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-e43a11d9d7444dbc9f5e8a4b95efafba2022-12-21T21:19:43ZengBMCMolecular Neurodegeneration1750-13262021-11-0116111610.1186/s13024-021-00496-7The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectivesHannah Walgrave0Lujia Zhou1Bart De Strooper2Evgenia Salta3VIB Center for Brain & Disease ResearchDivision of Janssen Pharmaceutica NV, Discovery Neuroscience, Janssen Research and DevelopmentVIB Center for Brain & Disease ResearchNetherlands Institute for NeuroscienceAbstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation of their regulatory potential in healthy and diseased brain. However, systematic interrogation of putative therapeutic or toxic effects of microRNAs in (models of) Alzheimer’s disease is currently missing and fundamental research findings are yet to be translated into clinical applications. Here, we review the literature to summarize the knowledge on microRNA regulation in Alzheimer’s pathophysiology and to critically discuss whether and to what extent these increasing insights can be exploited for the development of microRNA-based therapeutics in the clinic.https://doi.org/10.1186/s13024-021-00496-7microRNAAlzheimer’s diseasetherapeuticsneurodegenerative diseases |
| spellingShingle | Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives Molecular Neurodegeneration microRNA Alzheimer’s disease therapeutics neurodegenerative diseases |
| title | The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives |
| title_full | The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives |
| title_fullStr | The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives |
| title_full_unstemmed | The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives |
| title_short | The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives |
| title_sort | promise of microrna based therapies in alzheimer s disease challenges and perspectives |
| topic | microRNA Alzheimer’s disease therapeutics neurodegenerative diseases |
| url | https://doi.org/10.1186/s13024-021-00496-7 |
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