Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis
Abstract Background Intraductal papillary mucinous neoplasm (IPMN) is a cystic tumor of the pancreas arising from abnormal papillary proliferation of ductal epithelial cells, and is a precancerous lesion of pancreatic malignancy. This study aimed to evaluate associations between acute pancreatitis (...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-02972-4 |
| _version_ | 1827603577440305152 |
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| author | Ji-Hao Xu Chu-Yan Ni Yan-Yan Zhuang Li Li Ying Lin Zhong-Sheng Xia Wei-Rong Wu Qi-Kui Chen Wa Zhong |
| author_facet | Ji-Hao Xu Chu-Yan Ni Yan-Yan Zhuang Li Li Ying Lin Zhong-Sheng Xia Wei-Rong Wu Qi-Kui Chen Wa Zhong |
| author_sort | Ji-Hao Xu |
| collection | DOAJ |
| description | Abstract Background Intraductal papillary mucinous neoplasm (IPMN) is a cystic tumor of the pancreas arising from abnormal papillary proliferation of ductal epithelial cells, and is a precancerous lesion of pancreatic malignancy. This study aimed to evaluate associations between acute pancreatitis (AP) and histologic subtypes of IPMN. Methods In the clinical study, patients with IPMN confirmed by surgical resection specimens at our institute between 2009 and 2021 were eligible for inclusion. Associations and predictive accuracy of AP on the presence of HGD were determined by logistic regressions. In addition, a systematic review and meta-analysis was conducted through literatures upon search in PubMed, Embase, CENTRAL, China National Knowledge Infrastructure (CKNI), and Wanfang database, up to June, 2023. Pooled effects of the associations between AP and HGD and intestinal epithelial subtype subtype, shown as odds ratios (ORs) with 95% confidence intervals (CIs), were calculated using random effects model. Results The retrospective cohort study included 47 patients (32 males, 15 females) diagnosed with IPMN at our center between 2009 and 2021, including 11 cases with AP (median 62 years) and 36 cases (median 64.5 years) without. Accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of AP in predicting HGD were 78.7%, 57.1%, 82.5%, 36.4%, and 91.7%, respectively. Univariate logistic regression analysis showed that AP group had greater odds of presence of HGD (OR: 6.29,95% CI: 1.14–34.57) than non-AP group. Meta-analysis of five case-control studies in the literature included 930 patients and showed that AP-IPMN patients had higher odds for HGD (OR: 2.13, 95% CI 1.38–3.29) and intestinal epithelial subtype (OR: 5.38, 95% CI: 3.50–8.27) compared to non-AP IPMN. Conclusions AP is predictive of malignancy in patients with IPMN. |
| first_indexed | 2024-03-09T05:41:41Z |
| format | Article |
| id | doaj.art-e43b60d8d4954709a6f43f073b2acc49 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-09T05:41:41Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-e43b60d8d4954709a6f43f073b2acc492023-12-03T12:24:44ZengBMCBMC Gastroenterology1471-230X2023-12-0123111010.1186/s12876-023-02972-4Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysisJi-Hao Xu0Chu-Yan Ni1Yan-Yan Zhuang2Li Li3Ying Lin4Zhong-Sheng Xia5Wei-Rong Wu6Qi-Kui Chen7Wa Zhong8Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Emergency, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityAbstract Background Intraductal papillary mucinous neoplasm (IPMN) is a cystic tumor of the pancreas arising from abnormal papillary proliferation of ductal epithelial cells, and is a precancerous lesion of pancreatic malignancy. This study aimed to evaluate associations between acute pancreatitis (AP) and histologic subtypes of IPMN. Methods In the clinical study, patients with IPMN confirmed by surgical resection specimens at our institute between 2009 and 2021 were eligible for inclusion. Associations and predictive accuracy of AP on the presence of HGD were determined by logistic regressions. In addition, a systematic review and meta-analysis was conducted through literatures upon search in PubMed, Embase, CENTRAL, China National Knowledge Infrastructure (CKNI), and Wanfang database, up to June, 2023. Pooled effects of the associations between AP and HGD and intestinal epithelial subtype subtype, shown as odds ratios (ORs) with 95% confidence intervals (CIs), were calculated using random effects model. Results The retrospective cohort study included 47 patients (32 males, 15 females) diagnosed with IPMN at our center between 2009 and 2021, including 11 cases with AP (median 62 years) and 36 cases (median 64.5 years) without. Accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of AP in predicting HGD were 78.7%, 57.1%, 82.5%, 36.4%, and 91.7%, respectively. Univariate logistic regression analysis showed that AP group had greater odds of presence of HGD (OR: 6.29,95% CI: 1.14–34.57) than non-AP group. Meta-analysis of five case-control studies in the literature included 930 patients and showed that AP-IPMN patients had higher odds for HGD (OR: 2.13, 95% CI 1.38–3.29) and intestinal epithelial subtype (OR: 5.38, 95% CI: 3.50–8.27) compared to non-AP IPMN. Conclusions AP is predictive of malignancy in patients with IPMN.https://doi.org/10.1186/s12876-023-02972-4Acute pancreatitis (AP)Malignant intraductal papillary mucinous neoplasm (IPMN)High grade dysplasia (HGD) |
| spellingShingle | Ji-Hao Xu Chu-Yan Ni Yan-Yan Zhuang Li Li Ying Lin Zhong-Sheng Xia Wei-Rong Wu Qi-Kui Chen Wa Zhong Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis BMC Gastroenterology Acute pancreatitis (AP) Malignant intraductal papillary mucinous neoplasm (IPMN) High grade dysplasia (HGD) |
| title | Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis |
| title_full | Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis |
| title_fullStr | Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis |
| title_full_unstemmed | Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis |
| title_short | Acute pancreatitis in intraductal papillary mucinous neoplasm: a single-center retrospective cohort study with systematic review and meta-analysis |
| title_sort | acute pancreatitis in intraductal papillary mucinous neoplasm a single center retrospective cohort study with systematic review and meta analysis |
| topic | Acute pancreatitis (AP) Malignant intraductal papillary mucinous neoplasm (IPMN) High grade dysplasia (HGD) |
| url | https://doi.org/10.1186/s12876-023-02972-4 |
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