Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors
Growing antibiotic resistance complicates <i>H. pylori</i> eradication, posing a public health challenge. Inconclusive research on sociodemographic and clinical factors emphasizes the necessity for further investigations. Hence, this study aims to evaluate the correlation between demogra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/3/211 |
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| author | Sumaira Khadim Iyad Naeem Muhammad Tanveer Alam Shahnaz Usman Hina Rehman Sajjad Haider |
| author_facet | Sumaira Khadim Iyad Naeem Muhammad Tanveer Alam Shahnaz Usman Hina Rehman Sajjad Haider |
| author_sort | Sumaira Khadim |
| collection | DOAJ |
| description | Growing antibiotic resistance complicates <i>H. pylori</i> eradication, posing a public health challenge. Inconclusive research on sociodemographic and clinical factors emphasizes the necessity for further investigations. Hence, this study aims to evaluate the correlation between demographic and clinical factors and the success rates of <i>H. pylori</i> eradication. A group of 162 <i>H. pylori</i>-positive patients were allocated randomly to receive either a ten-day moxifloxacin-based triple therapy or a levofloxacin-based sequential therapy. Eradication success was determined through the stool antigen test. Logistic regression analysis was utilized to figure out potential factors that contribute to <i>H. pylori</i> eradication success. Significantly higher <i>H. pylori</i> eradication rates were observed in the middle age group (COR: 3.671, <i>p</i> = 0.007), among females (<i>p</i> = 0.035), those with BMI ≥ 25 (COR: 2.011, <i>p</i> = 0.045), and non-smokers (COR: 2.718, <i>p</i> = 0.018). In multivariate analysis, age and smoking emerged as significant predictors (<i>p</i> < 0.05). Patients with comorbidities, excluding diabetes and hypertension (COR: 4.432, <i>p</i> = 0.019), dyspepsia (COR: 0.178, <i>p</i> < 0.001), and moxifloxacin triple therapy (COR: 0.194, <i>p</i> = 0.000), exhibited higher chances of eradication (<i>p</i> < 0.05). Further research is vital for tailored approaches to enhance eradication success. |
| first_indexed | 2024-04-24T18:37:14Z |
| format | Article |
| id | doaj.art-e43c6e4b1c74402bb325d5ffd065bfdc |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-24T18:37:14Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e43c6e4b1c74402bb325d5ffd065bfdc2024-03-27T13:18:05ZengMDPI AGAntibiotics2079-63822024-02-0113321110.3390/antibiotics13030211Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical FactorsSumaira Khadim0Iyad Naeem Muhammad1Tanveer Alam2Shahnaz Usman3Hina Rehman4Sajjad Haider5Faculty of Health Sciences, Iqra University of Health Sciences, Karachi 75500, PakistanFaculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi 75270, PakistanJamal Noor Hospital, Karachi 74800, PakistanRAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesInstitute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi 75510, PakistanFaculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi 75270, PakistanGrowing antibiotic resistance complicates <i>H. pylori</i> eradication, posing a public health challenge. Inconclusive research on sociodemographic and clinical factors emphasizes the necessity for further investigations. Hence, this study aims to evaluate the correlation between demographic and clinical factors and the success rates of <i>H. pylori</i> eradication. A group of 162 <i>H. pylori</i>-positive patients were allocated randomly to receive either a ten-day moxifloxacin-based triple therapy or a levofloxacin-based sequential therapy. Eradication success was determined through the stool antigen test. Logistic regression analysis was utilized to figure out potential factors that contribute to <i>H. pylori</i> eradication success. Significantly higher <i>H. pylori</i> eradication rates were observed in the middle age group (COR: 3.671, <i>p</i> = 0.007), among females (<i>p</i> = 0.035), those with BMI ≥ 25 (COR: 2.011, <i>p</i> = 0.045), and non-smokers (COR: 2.718, <i>p</i> = 0.018). In multivariate analysis, age and smoking emerged as significant predictors (<i>p</i> < 0.05). Patients with comorbidities, excluding diabetes and hypertension (COR: 4.432, <i>p</i> = 0.019), dyspepsia (COR: 0.178, <i>p</i> < 0.001), and moxifloxacin triple therapy (COR: 0.194, <i>p</i> = 0.000), exhibited higher chances of eradication (<i>p</i> < 0.05). Further research is vital for tailored approaches to enhance eradication success.https://www.mdpi.com/2079-6382/13/3/211<i>H. pylori</i>demographic variablesclinical variableseradication failuremoxifloxacinlevofloxacin |
| spellingShingle | Sumaira Khadim Iyad Naeem Muhammad Tanveer Alam Shahnaz Usman Hina Rehman Sajjad Haider Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors Antibiotics <i>H. pylori</i> demographic variables clinical variables eradication failure moxifloxacin levofloxacin |
| title | Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors |
| title_full | Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors |
| title_fullStr | Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors |
| title_full_unstemmed | Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors |
| title_short | Predictors of Successful First-Line <i>Helicobacter pylori</i> Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors |
| title_sort | predictors of successful first line i helicobacter pylori i eradication with fluoroquinolones in pakistan a prospective exploration of demographic and clinical factors |
| topic | <i>H. pylori</i> demographic variables clinical variables eradication failure moxifloxacin levofloxacin |
| url | https://www.mdpi.com/2079-6382/13/3/211 |
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