Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain
The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and repres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/2/30 |
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| author | Anna A. Antsiferova Marina Yu. Kopaeva Vyacheslav N. Kochkin Pavel K. Kashkarov Mikhail V. Kovalchuk |
| author_facet | Anna A. Antsiferova Marina Yu. Kopaeva Vyacheslav N. Kochkin Pavel K. Kashkarov Mikhail V. Kovalchuk |
| author_sort | Anna A. Antsiferova |
| collection | DOAJ |
| description | The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred. |
| first_indexed | 2024-03-09T05:53:44Z |
| format | Article |
| id | doaj.art-e43d177f6bae4e33ad13d65a417547f9 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T05:53:44Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-e43d177f6bae4e33ad13d65a417547f92023-12-03T12:15:24ZengMDPI AGToxics2305-63042021-02-01923010.3390/toxics9020030Disturbance in Mammalian Cognition Caused by Accumulation of Silver in BrainAnna A. Antsiferova0Marina Yu. Kopaeva1Vyacheslav N. Kochkin2Pavel K. Kashkarov3Mikhail V. Kovalchuk4National Research Center “Kurchatov Institute”, 1, Akademika Kurchatova sq., 123182 Moscow, RussiaNational Research Center “Kurchatov Institute”, 1, Akademika Kurchatova sq., 123182 Moscow, RussiaNational Research Center “Kurchatov Institute”, 1, Akademika Kurchatova sq., 123182 Moscow, RussiaNational Research Center “Kurchatov Institute”, 1, Akademika Kurchatova sq., 123182 Moscow, RussiaNational Research Center “Kurchatov Institute”, 1, Akademika Kurchatova sq., 123182 Moscow, RussiaThe influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.https://www.mdpi.com/2305-6304/9/2/30silver nanoparticlescontextual memoryaccumulation in brainbiodistributionhippocampuscerebellum |
| spellingShingle | Anna A. Antsiferova Marina Yu. Kopaeva Vyacheslav N. Kochkin Pavel K. Kashkarov Mikhail V. Kovalchuk Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain Toxics silver nanoparticles contextual memory accumulation in brain biodistribution hippocampus cerebellum |
| title | Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain |
| title_full | Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain |
| title_fullStr | Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain |
| title_full_unstemmed | Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain |
| title_short | Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain |
| title_sort | disturbance in mammalian cognition caused by accumulation of silver in brain |
| topic | silver nanoparticles contextual memory accumulation in brain biodistribution hippocampus cerebellum |
| url | https://www.mdpi.com/2305-6304/9/2/30 |
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