Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial
Background and PurposeThe evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke.MethodsWe retrospectively studied patients with acute ischemic stroke enrolle...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.747343/full |
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| author | Ning Bu Ning Bu Leonid Churilov Leonid Churilov Mohamed Salah Khlif Robin Lemmens Robin Lemmens Robin Lemmens Anke Wouters Anke Wouters Anke Wouters Jochen B. Fiebach Angel Chamorro E. Bernd Ringelstein Bo Norrving Rico Laage Martin Grond Guido Wilms Amy Brodtmann Vincent Thijs |
| author_facet | Ning Bu Ning Bu Leonid Churilov Leonid Churilov Mohamed Salah Khlif Robin Lemmens Robin Lemmens Robin Lemmens Anke Wouters Anke Wouters Anke Wouters Jochen B. Fiebach Angel Chamorro E. Bernd Ringelstein Bo Norrving Rico Laage Martin Grond Guido Wilms Amy Brodtmann Vincent Thijs |
| author_sort | Ning Bu |
| collection | DOAJ |
| description | Background and PurposeThe evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke.MethodsWe retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed.ResultsWe enrolled 173 patients with a mean age of 67 ± 11 years, 44% were women. There was a median 6 ml decrease in volume (25th percentile −1 ml to 75th percentile 21 ml) over time, equivalent to a median 0.5% (interquartile range [IQR], −0.07%−1.4%), decrease in brain volume. Age was associated with larger brain volume loss (per 10 years of age, 5 ml 95% CI 2–8 ml). Baseline diffusion weighted imaging (DWI) lesion volume was not associated with greater volume loss per 10 ml of lesion volume, change by 0 ml (95% CI −0.1 to 0.1 ml). Increasing Fazekas scores of deep WMH were associated with greater tissue loss (5 ml, 95% CI 1–10 ml).ConclusionsTotal brain volume changes in a heterogenous fashion after stroke. Volume loss occurs over 1 month after stroke and is associated with age and deep WM disease. We did not find evidence that more severe strokes lead to increased early tissue loss. |
| first_indexed | 2024-04-11T18:16:51Z |
| format | Article |
| id | doaj.art-e43e533e2b0f44ca89eb51f0cf9725b9 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T18:16:51Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e43e533e2b0f44ca89eb51f0cf9725b92022-12-22T04:09:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-01-011210.3389/fneur.2021.747343747343Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 TrialNing Bu0Ning Bu1Leonid Churilov2Leonid Churilov3Mohamed Salah Khlif4Robin Lemmens5Robin Lemmens6Robin Lemmens7Anke Wouters8Anke Wouters9Anke Wouters10Jochen B. Fiebach11Angel Chamorro12E. Bernd Ringelstein13Bo Norrving14Rico Laage15Martin Grond16Guido Wilms17Amy Brodtmann18Vincent Thijs19Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaStroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, AustraliaDepartment of Medicine and Neurology, Melbourne Brain Centre, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Medicine, University of Melbourne, Melbourne, VIC, AustraliaDementia Theme, The Florey Institute for Neuroscience and Mental Health, Parkville, VIC, AustraliaDepartment of Neurosciences, Experimental Neurology, KU Leuven – University of Leuven, Leuven, BelgiumLaboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, BelgiumDepartment of Neurology, University Hospitals Leuven, Leuven, BelgiumDepartment of Neurosciences, Experimental Neurology, KU Leuven – University of Leuven, Leuven, BelgiumLaboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, BelgiumDepartment of Neurology, University Hospitals Leuven, Leuven, BelgiumCenter for Stroke Research, Charité University Medicine Berlin, Berlin, Germany0Department of Neurology, University of Barcelona, Barcelona, Spain1Department of Neurology, Wilhelms University of Muenster, Münster, Germany2Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden3Department of Clinical Research, Guided Development GmbH, Heidelberg, Germany4Department of Neurology, Kreisklinikum Siegen, University of Marburg Germany, Marburg, Germany5Department of Radiology, University Hospitals of Leuven, Leuven, BelgiumDementia Theme, The Florey Institute for Neuroscience and Mental Health, Parkville, VIC, AustraliaStroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, AustraliaBackground and PurposeThe evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke.MethodsWe retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed.ResultsWe enrolled 173 patients with a mean age of 67 ± 11 years, 44% were women. There was a median 6 ml decrease in volume (25th percentile −1 ml to 75th percentile 21 ml) over time, equivalent to a median 0.5% (interquartile range [IQR], −0.07%−1.4%), decrease in brain volume. Age was associated with larger brain volume loss (per 10 years of age, 5 ml 95% CI 2–8 ml). Baseline diffusion weighted imaging (DWI) lesion volume was not associated with greater volume loss per 10 ml of lesion volume, change by 0 ml (95% CI −0.1 to 0.1 ml). Increasing Fazekas scores of deep WMH were associated with greater tissue loss (5 ml, 95% CI 1–10 ml).ConclusionsTotal brain volume changes in a heterogenous fashion after stroke. Volume loss occurs over 1 month after stroke and is associated with age and deep WM disease. We did not find evidence that more severe strokes lead to increased early tissue loss.https://www.frontiersin.org/articles/10.3389/fneur.2021.747343/fullischemic strokebrain volume changesatrophyclinical trialhemorrhagic transformationedema |
| spellingShingle | Ning Bu Ning Bu Leonid Churilov Leonid Churilov Mohamed Salah Khlif Robin Lemmens Robin Lemmens Robin Lemmens Anke Wouters Anke Wouters Anke Wouters Jochen B. Fiebach Angel Chamorro E. Bernd Ringelstein Bo Norrving Rico Laage Martin Grond Guido Wilms Amy Brodtmann Vincent Thijs Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial Frontiers in Neurology ischemic stroke brain volume changes atrophy clinical trial hemorrhagic transformation edema |
| title | Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial |
| title_full | Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial |
| title_fullStr | Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial |
| title_full_unstemmed | Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial |
| title_short | Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial |
| title_sort | early brain volume changes after stroke subgroup analysis from the axis 2 trial |
| topic | ischemic stroke brain volume changes atrophy clinical trial hemorrhagic transformation edema |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.747343/full |
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