Molecular markers (c-erbB-2, p53) in breast cancer.
The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2009-01-01
|
| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/4403 |
| _version_ | 1811230928779870208 |
|---|---|
| author | Piotr Zukrowski Zygmunt Grzebieniak Jerzy Rudnicki Michał Jeleń Anil Kumar Agrawal Ewa Nienartowicz |
| author_facet | Piotr Zukrowski Zygmunt Grzebieniak Jerzy Rudnicki Michał Jeleń Anil Kumar Agrawal Ewa Nienartowicz |
| author_sort | Piotr Zukrowski |
| collection | DOAJ |
| description | The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were divided into two groups - 64 belonged to the premenopausal group and 120 to postmenopausal group. Each patient underwent mammectomy and axillary lymphadenectomy. c-erbB-2 protooncogene was detected in 54% cases, and was correlated with infiltrating type of cancer growth, as well as larger tumor size. The presence of p53 antioncogene was observed only in 33% of cases, mainly in infiltrating duct carcinomas. The incidence of c-erbB-2 and p53 positive cases was higher among subjects, whose ultrasound and mammography revealed malignancy. There was no correlation found between of c-erbB-2 expression and axillary lymph nodes involvement It seems probable, that c-erbB-2 and p53 status of cancer tissue may prove to be useful in assessment of the level of biological aggressiveness in breast carcinomas and hence can be used as a prognostic factor. |
| first_indexed | 2024-04-12T10:36:29Z |
| format | Article |
| id | doaj.art-e43e70ee30b74c3c88c67b726c09d8e5 |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-04-12T10:36:29Z |
| publishDate | 2009-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-e43e70ee30b74c3c88c67b726c09d8e52022-12-22T03:36:42ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312009-01-0146444945510.5603/4403Molecular markers (c-erbB-2, p53) in breast cancer.Piotr ZukrowskiZygmunt GrzebieniakJerzy RudnickiMichał JeleńAnil Kumar AgrawalEwa NienartowiczThe aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were divided into two groups - 64 belonged to the premenopausal group and 120 to postmenopausal group. Each patient underwent mammectomy and axillary lymphadenectomy. c-erbB-2 protooncogene was detected in 54% cases, and was correlated with infiltrating type of cancer growth, as well as larger tumor size. The presence of p53 antioncogene was observed only in 33% of cases, mainly in infiltrating duct carcinomas. The incidence of c-erbB-2 and p53 positive cases was higher among subjects, whose ultrasound and mammography revealed malignancy. There was no correlation found between of c-erbB-2 expression and axillary lymph nodes involvement It seems probable, that c-erbB-2 and p53 status of cancer tissue may prove to be useful in assessment of the level of biological aggressiveness in breast carcinomas and hence can be used as a prognostic factor.http://czasopisma.viamedica.pl/fhc/article/view/4403 |
| spellingShingle | Piotr Zukrowski Zygmunt Grzebieniak Jerzy Rudnicki Michał Jeleń Anil Kumar Agrawal Ewa Nienartowicz Molecular markers (c-erbB-2, p53) in breast cancer. Folia Histochemica et Cytobiologica |
| title | Molecular markers (c-erbB-2, p53) in breast cancer. |
| title_full | Molecular markers (c-erbB-2, p53) in breast cancer. |
| title_fullStr | Molecular markers (c-erbB-2, p53) in breast cancer. |
| title_full_unstemmed | Molecular markers (c-erbB-2, p53) in breast cancer. |
| title_short | Molecular markers (c-erbB-2, p53) in breast cancer. |
| title_sort | molecular markers c erbb 2 p53 in breast cancer |
| url | http://czasopisma.viamedica.pl/fhc/article/view/4403 |
| work_keys_str_mv | AT piotrzukrowski molecularmarkerscerbb2p53inbreastcancer AT zygmuntgrzebieniak molecularmarkerscerbb2p53inbreastcancer AT jerzyrudnicki molecularmarkerscerbb2p53inbreastcancer AT michałjelen molecularmarkerscerbb2p53inbreastcancer AT anilkumaragrawal molecularmarkerscerbb2p53inbreastcancer AT ewanienartowicz molecularmarkerscerbb2p53inbreastcancer |