Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses
Recommendations for duration of treatment with antipsychotics before considering a switch vary from 2 to 8 weeks, although several studies suggest a rapid onset of action. The objective of this review was to estimate time to onset of action and time to maximum antipsychotic effect of asenapine, olan...
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/82 |
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| author | Rikke Meyer Kenneth Skov Inderjeet Kaur Dhillon Emilie Olsson Niels Albert Graudal Lone Baandrup Gesche Jürgens |
| author_facet | Rikke Meyer Kenneth Skov Inderjeet Kaur Dhillon Emilie Olsson Niels Albert Graudal Lone Baandrup Gesche Jürgens |
| author_sort | Rikke Meyer |
| collection | DOAJ |
| description | Recommendations for duration of treatment with antipsychotics before considering a switch vary from 2 to 8 weeks, although several studies suggest a rapid onset of action. The objective of this review was to estimate time to onset of action and time to maximum antipsychotic effect of asenapine, olanzapine, quetiapine, and zotepine (pines). We searched bibliographic databases for randomized, placebo-controlled trials in adults with schizophrenia estimating the antipsychotic effect of pines over time. Thirty-five studies including 6331 patients diagnosed with chronic schizophrenia were included. We estimated the standardized mean differences (SMD) of changes in symptom score from baseline to follow-up between intervention and placebo groups across studies using meta-analysis techniques. The summarized effect across all included pines administered as immediate-release formulations showed a statistically significant effect at week 1 (SMD, −0.20 [CI95% −0.28, −0.13]), which increased until week 3 (SMD, −0.42 [CI95% −0.50, −0.34]), after which the effect leveled off (week 6: SMD, −0.53 [CI95% −0.62, −0.44]). The sensitivity analyses of the individual pines confirm this finding, although data sparsity increases variability and limits conclusiveness of these analyses. |
| first_indexed | 2024-03-09T13:30:40Z |
| format | Article |
| id | doaj.art-e43f2d4b3eb34aa39127e2f45e6fe2ba |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e43f2d4b3eb34aa39127e2f45e6fe2ba2023-11-30T21:19:11ZengMDPI AGBiomedicines2227-90592022-12-011118210.3390/biomedicines11010082Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-AnalysesRikke Meyer0Kenneth Skov1Inderjeet Kaur Dhillon2Emilie Olsson3Niels Albert Graudal4Lone Baandrup5Gesche Jürgens6Clinical Pharmacology Unit, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000 Roskilde, DenmarkClinical Pharmacology Unit, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000 Roskilde, DenmarkMental Health Services West, Psychiatry Region Zealand, 4200 Slagelse, DenmarkClinical Pharmacology Unit, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000 Roskilde, DenmarkLupus and Vasculitis Clinic VRR4242, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, DenmarkClinical Pharmacology Unit, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000 Roskilde, DenmarkRecommendations for duration of treatment with antipsychotics before considering a switch vary from 2 to 8 weeks, although several studies suggest a rapid onset of action. The objective of this review was to estimate time to onset of action and time to maximum antipsychotic effect of asenapine, olanzapine, quetiapine, and zotepine (pines). We searched bibliographic databases for randomized, placebo-controlled trials in adults with schizophrenia estimating the antipsychotic effect of pines over time. Thirty-five studies including 6331 patients diagnosed with chronic schizophrenia were included. We estimated the standardized mean differences (SMD) of changes in symptom score from baseline to follow-up between intervention and placebo groups across studies using meta-analysis techniques. The summarized effect across all included pines administered as immediate-release formulations showed a statistically significant effect at week 1 (SMD, −0.20 [CI95% −0.28, −0.13]), which increased until week 3 (SMD, −0.42 [CI95% −0.50, −0.34]), after which the effect leveled off (week 6: SMD, −0.53 [CI95% −0.62, −0.44]). The sensitivity analyses of the individual pines confirm this finding, although data sparsity increases variability and limits conclusiveness of these analyses.https://www.mdpi.com/2227-9059/11/1/82antipsychotic actionantipsychotic effectantipsychotic agentspinespsychopharmacologyschizophrenia |
| spellingShingle | Rikke Meyer Kenneth Skov Inderjeet Kaur Dhillon Emilie Olsson Niels Albert Graudal Lone Baandrup Gesche Jürgens Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses Biomedicines antipsychotic action antipsychotic effect antipsychotic agents pines psychopharmacology schizophrenia |
| title | Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses |
| title_full | Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses |
| title_fullStr | Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses |
| title_full_unstemmed | Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses |
| title_short | Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses |
| title_sort | onset of action of selected second generation antipsychotics pines a systematic review and meta analyses |
| topic | antipsychotic action antipsychotic effect antipsychotic agents pines psychopharmacology schizophrenia |
| url | https://www.mdpi.com/2227-9059/11/1/82 |
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