Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation
Abstract A precise quantification of mitral regurgitation (MR) severity is essential for treatment and outcome of patients with MR. 3D echocardiography facilitates estimation of MR but selection of patients with necessity of invasive treatment remains challenging. We investigate effective regurgitat...
| Asıl Yazarlar: | , , , , , , , , , , , , , |
|---|---|
| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Nature Portfolio
2024-09-01
|
| Seri Bilgileri: | Scientific Reports |
| Konular: | |
| Online Erişim: | https://doi.org/10.1038/s41598-024-73264-4 |
| _version_ | 1827098718099210240 |
|---|---|
| author | Tobias Harm Frederic-Joaquim Schwarz Monika Zdanyte Andreas Goldschmied Livia Baas Parwez Aidery Serhii Shcherbyna Ioannis Toskas Timea Keller Isabela Kast Juergen Schreieck Tobias Geisler Meinrad Paul Gawaz Karin Anne Lydia Mueller |
| author_facet | Tobias Harm Frederic-Joaquim Schwarz Monika Zdanyte Andreas Goldschmied Livia Baas Parwez Aidery Serhii Shcherbyna Ioannis Toskas Timea Keller Isabela Kast Juergen Schreieck Tobias Geisler Meinrad Paul Gawaz Karin Anne Lydia Mueller |
| author_sort | Tobias Harm |
| collection | DOAJ |
| description | Abstract A precise quantification of mitral regurgitation (MR) severity is essential for treatment and outcome of patients with MR. 3D echocardiography facilitates estimation of MR but selection of patients with necessity of invasive treatment remains challenging. We investigate effective regurgitation orifice area (EROA) quantification by 3D compared to 2D echocardiography in patients with MR and highlight the improved discrimination of MR severity. We consecutively enrolled fifty patients with primary or secondary and at least moderate MR undergoing 2D and 3D colour Doppler echocardiography prior to transcatheter edge-to-edge repair (TEER). Improved accuracy of MR grading using 3D vena contracta area (VCA) as an estimate of EROA was compared to 2D proximal isovelocity surface area (PISA) quantification method and a multiparameter reference standard. Quantification of EROA remarkably varies between 2D and 3D echocardiography and the discrimination between moderate and severe MR was significantly (p = 0.001) different using 2D PISA or 3D VCA, respectively. 3D VCA correlated significantly (r = 0.501, p < 0.001) better with the pre-defined MR severity. We detected crucial differences in the correct identification of severe MR between 2D and 3D techniques, thus 2D PISA significantly (p < 0.0001) underestimates EROA due to clinical and morphological parameters. The assessment of 3D VCA resulted in improved diagnostic accuracy. |
| first_indexed | 2025-03-20T07:52:00Z |
| format | Article |
| id | doaj.art-e43f3adb3d2140c98e40d38db1d9025f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2025-03-20T07:52:00Z |
| publishDate | 2024-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e43f3adb3d2140c98e40d38db1d9025f2024-09-29T11:23:24ZengNature PortfolioScientific Reports2045-23222024-09-0114111110.1038/s41598-024-73264-4Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitationTobias Harm0Frederic-Joaquim Schwarz1Monika Zdanyte2Andreas Goldschmied3Livia Baas4Parwez Aidery5Serhii Shcherbyna6Ioannis Toskas7Timea Keller8Isabela Kast9Juergen Schreieck10Tobias Geisler11Meinrad Paul Gawaz12Karin Anne Lydia Mueller13Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University TübingenAbstract A precise quantification of mitral regurgitation (MR) severity is essential for treatment and outcome of patients with MR. 3D echocardiography facilitates estimation of MR but selection of patients with necessity of invasive treatment remains challenging. We investigate effective regurgitation orifice area (EROA) quantification by 3D compared to 2D echocardiography in patients with MR and highlight the improved discrimination of MR severity. We consecutively enrolled fifty patients with primary or secondary and at least moderate MR undergoing 2D and 3D colour Doppler echocardiography prior to transcatheter edge-to-edge repair (TEER). Improved accuracy of MR grading using 3D vena contracta area (VCA) as an estimate of EROA was compared to 2D proximal isovelocity surface area (PISA) quantification method and a multiparameter reference standard. Quantification of EROA remarkably varies between 2D and 3D echocardiography and the discrimination between moderate and severe MR was significantly (p = 0.001) different using 2D PISA or 3D VCA, respectively. 3D VCA correlated significantly (r = 0.501, p < 0.001) better with the pre-defined MR severity. We detected crucial differences in the correct identification of severe MR between 2D and 3D techniques, thus 2D PISA significantly (p < 0.0001) underestimates EROA due to clinical and morphological parameters. The assessment of 3D VCA resulted in improved diagnostic accuracy.https://doi.org/10.1038/s41598-024-73264-4Mitral regurgitationEffective regurgitation orifice area3D EROAThree-dimensional EchocardiographyVena Contracta AreaDiagnostic value |
| spellingShingle | Tobias Harm Frederic-Joaquim Schwarz Monika Zdanyte Andreas Goldschmied Livia Baas Parwez Aidery Serhii Shcherbyna Ioannis Toskas Timea Keller Isabela Kast Juergen Schreieck Tobias Geisler Meinrad Paul Gawaz Karin Anne Lydia Mueller Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation Scientific Reports Mitral regurgitation Effective regurgitation orifice area 3D EROA Three-dimensional Echocardiography Vena Contracta Area Diagnostic value |
| title | Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| title_full | Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| title_fullStr | Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| title_full_unstemmed | Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| title_short | Novel 3-dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| title_sort | novel 3 dimensional effective regurgitation orifice area quantification serves as a reliable tool to identify severe mitral valve regurgitation |
| topic | Mitral regurgitation Effective regurgitation orifice area 3D EROA Three-dimensional Echocardiography Vena Contracta Area Diagnostic value |
| url | https://doi.org/10.1038/s41598-024-73264-4 |
| work_keys_str_mv | AT tobiasharm novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT fredericjoaquimschwarz novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT monikazdanyte novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT andreasgoldschmied novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT liviabaas novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT parwezaidery novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT serhiishcherbyna novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT ioannistoskas novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT timeakeller novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT isabelakast novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT juergenschreieck novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT tobiasgeisler novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT meinradpaulgawaz novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation AT karinannelydiamueller novel3dimensionaleffectiveregurgitationorificeareaquantificationservesasareliabletooltoidentifyseveremitralvalveregurgitation |