Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma
Mucosal melanoma is a rare and aggressive neoplasm of melanocytic origin. To date, in literature only few retrospective series and case reports have been reported on mucosal melanoma. Despite melanoma’s common histological origin,molecular biology of upper aerodigestive tract mucosal melanoma has so...
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| Format: | Article |
| Language: | Russian |
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IP Habib O.N.
2016-12-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/view/27091 |
| _version_ | 1819106657377976320 |
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| author | A V Ignatova |
| author_facet | A V Ignatova |
| author_sort | A V Ignatova |
| collection | DOAJ |
| description | Mucosal melanoma is a rare and aggressive neoplasm of melanocytic origin. To date, in literature only few retrospective series and case reports have been reported on mucosal melanoma. Despite melanoma’s common histological origin,molecular biology of upper aerodigestive tract mucosal melanoma has some specific features compared with those of cutaneous melanomas. Taking into concideration the tremendous number of studies of prognostic molecular markers in cancer, only a few such markers have entered clinical practice in mucosal melanoma. The incidence of activating mutations in the BRAF, C-KIT and N-RAS oncogenes in mucosal melanoma is quite different from cutaneous melanoma: upper aerodigestive tract melanoma is characterized by high incidence of C-KIT and N-RAS mutations, BRAF mutations are uncommon. The most frequently studied markers in upper aerodigestive tract mucosal melanoma and prospectives of targeted therapy are reviewed in this article. A better comprehension of the pathogenesis of disease, in particular its molecular aberrations, can provide important insights into targets for future therapies. |
| first_indexed | 2024-12-22T02:41:37Z |
| format | Article |
| id | doaj.art-e43f8c917dc94a3dbe7efb3a50e3c021 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-12-22T02:41:37Z |
| publishDate | 2016-12-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-e43f8c917dc94a3dbe7efb3a50e3c0212022-12-21T18:41:38ZrusIP Habib O.N.Современная онкология1815-14341815-14422016-12-01184424624311Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanomaA V Ignatova0Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian FederationMucosal melanoma is a rare and aggressive neoplasm of melanocytic origin. To date, in literature only few retrospective series and case reports have been reported on mucosal melanoma. Despite melanoma’s common histological origin,molecular biology of upper aerodigestive tract mucosal melanoma has some specific features compared with those of cutaneous melanomas. Taking into concideration the tremendous number of studies of prognostic molecular markers in cancer, only a few such markers have entered clinical practice in mucosal melanoma. The incidence of activating mutations in the BRAF, C-KIT and N-RAS oncogenes in mucosal melanoma is quite different from cutaneous melanoma: upper aerodigestive tract melanoma is characterized by high incidence of C-KIT and N-RAS mutations, BRAF mutations are uncommon. The most frequently studied markers in upper aerodigestive tract mucosal melanoma and prospectives of targeted therapy are reviewed in this article. A better comprehension of the pathogenesis of disease, in particular its molecular aberrations, can provide important insights into targets for future therapies.https://modernonco.orscience.ru/1815-1434/article/view/27091ras/raf/mek/erkn-raskithead and neckmucosal melanomacutaneous melanomaoncogenemutationtargeted therapysignaling pathway pi3k-akt-mtorras/raf/mek/erkmutations brafn-raskit |
| spellingShingle | A V Ignatova Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma Современная онкология ras/raf/mek/erk n-ras kit head and neck mucosal melanoma cutaneous melanoma oncogene mutation targeted therapy signaling pathway pi3k-akt-mtor ras/raf/mek/erk mutations braf n-ras kit |
| title | Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma |
| title_full | Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma |
| title_fullStr | Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma |
| title_full_unstemmed | Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma |
| title_short | Molecular genetic features of the head and neck (upper aerodigestive tract) mucosal melanoma |
| title_sort | molecular genetic features of the head and neck upper aerodigestive tract mucosal melanoma |
| topic | ras/raf/mek/erk n-ras kit head and neck mucosal melanoma cutaneous melanoma oncogene mutation targeted therapy signaling pathway pi3k-akt-mtor ras/raf/mek/erk mutations braf n-ras kit |
| url | https://modernonco.orscience.ru/1815-1434/article/view/27091 |
| work_keys_str_mv | AT avignatova moleculargeneticfeaturesoftheheadandneckupperaerodigestivetractmucosalmelanoma |