Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds

Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds

The obligate intracellular bacterium <i>Chlamydia trachomatis</i> is the major causative agent of bacterial sexually transmitted diseases worldwide. In infected cells, the ceramide transport protein (CERT) is recruited to inclusions, where <i>C. trachomatis</i> replicates usi...

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Bibliographic Details
Main Authors: Keigo Kumagai, Shota Sakai, Masaharu Ueno, Michiyo Kataoka, Shu Kobayashi, Kentaro Hanada
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
infectious disease
<i>Chlamydia trachomatis</i>
bacterial metabolism
antibiotics
ceramide
sphingolipid
Online Access:https://www.mdpi.com/1422-0067/23/23/14697

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