Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age
Abstract Background In the entire population, an aberrant right subclavian artery (ARSA) is closely associated with chromosomal abnormalities. ARSA with additional ultrasonic findings would increase risk of chromosomal abnormalities. The risk of fetal chromosomal abnormalities increased exponentiall...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-021-03626-7 |
| _version_ | 1818415459650764800 |
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| author | Li-Ping Chen Yong-Feng Lai Xiao-Hong Zhong Jian-Hong You Jiang-Hua Chen Jing-Xian Xie Xiao-Kang Chen Xiao-Yan Chen Guo-Rong Lyu |
| author_facet | Li-Ping Chen Yong-Feng Lai Xiao-Hong Zhong Jian-Hong You Jiang-Hua Chen Jing-Xian Xie Xiao-Kang Chen Xiao-Yan Chen Guo-Rong Lyu |
| author_sort | Li-Ping Chen |
| collection | DOAJ |
| description | Abstract Background In the entire population, an aberrant right subclavian artery (ARSA) is closely associated with chromosomal abnormalities. ARSA with additional ultrasonic findings would increase risk of chromosomal abnormalities. The risk of fetal chromosomal abnormalities increased exponentially with the maternal age. These risks in the advanced maternal age (AMA) group are uncertain. This study aimed to determine the incidence of ARSA in Chinese AMA and non-AMA women and the frequency of aneuploidy among AMA and non-AMA women with ARSA. Methods This retrospective study included 13,690 singleton pregnancies, were divided into AMA and non-AMA groups. Integrated obstetric ultrasonic screening, biochemical screening, noninvasive prenatal screening, and fetal karyotype analysis were analyzed. Results The overall incidence of ARSA was 0.69%, with no difference between age groups. The incidence of chromosomal abnormalities in the AMA group (37 / 2860) was much higher than that of the non-AMA group. The risk of chromosomal abnormalities significantly increased with both ARSA detected and additional ultrasound findings. With combined ARSA and AMA, the likelihood of the incidence of chromosomal abnormalities increased. Chimerism (45X / 46XX) was found with isolated ARSA in AMA pregnancies. Conclusion There is a high prevalence of chromosomal abnormalities in fetuses of AMA women. ARSA increases the risk of chromosomal abnormalities in both age groups, especially combined with ARSA. When ARSA occurs in AMA women, it confers a high likelihood of chromosomal abnormalities. |
| first_indexed | 2024-12-14T11:35:20Z |
| format | Article |
| id | doaj.art-e440ec19ba7546ed959ddefe57b002a3 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-14T11:35:20Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-e440ec19ba7546ed959ddefe57b002a32022-12-21T23:03:04ZengBMCBMC Pregnancy and Childbirth1471-23932021-02-012111810.1186/s12884-021-03626-7Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal ageLi-Ping Chen0Yong-Feng Lai1Xiao-Hong Zhong2Jian-Hong You3Jiang-Hua Chen4Jing-Xian Xie5Xiao-Kang Chen6Xiao-Yan Chen7Guo-Rong Lyu8Department of Ultrasound, Women and Children’s Hospital, School of Medicine, Xiamen UniversityDepartment of Ultrasound, Wuping County HospitalDepartment of Ultrasound, Women and Children’s Hospital, School of Medicine, Xiamen UniversityDepartment of Ultrasound, Zhongshan Hospital of Xiamen UniversityDepartment of Ultrasound, Zhongshan Hospital of Xiamen UniversityDepartment of Obstetrics and Gynecology, Women and Children’s Hospital, School of Medicine, Xiamen UniversityDepartment of Ultrasound, Children’s Hospital of Fudan University Xiamen Branch, Xiamen Children’s HospitalDepartment of Ultrasound, Zhongshan Hospital of Xiamen UniversityDepartment of Clinical Medicine, Quanzhou Medical CollegeAbstract Background In the entire population, an aberrant right subclavian artery (ARSA) is closely associated with chromosomal abnormalities. ARSA with additional ultrasonic findings would increase risk of chromosomal abnormalities. The risk of fetal chromosomal abnormalities increased exponentially with the maternal age. These risks in the advanced maternal age (AMA) group are uncertain. This study aimed to determine the incidence of ARSA in Chinese AMA and non-AMA women and the frequency of aneuploidy among AMA and non-AMA women with ARSA. Methods This retrospective study included 13,690 singleton pregnancies, were divided into AMA and non-AMA groups. Integrated obstetric ultrasonic screening, biochemical screening, noninvasive prenatal screening, and fetal karyotype analysis were analyzed. Results The overall incidence of ARSA was 0.69%, with no difference between age groups. The incidence of chromosomal abnormalities in the AMA group (37 / 2860) was much higher than that of the non-AMA group. The risk of chromosomal abnormalities significantly increased with both ARSA detected and additional ultrasound findings. With combined ARSA and AMA, the likelihood of the incidence of chromosomal abnormalities increased. Chimerism (45X / 46XX) was found with isolated ARSA in AMA pregnancies. Conclusion There is a high prevalence of chromosomal abnormalities in fetuses of AMA women. ARSA increases the risk of chromosomal abnormalities in both age groups, especially combined with ARSA. When ARSA occurs in AMA women, it confers a high likelihood of chromosomal abnormalities.https://doi.org/10.1186/s12884-021-03626-7UltrasonographyFetusAberrant right subclavian arteryChromosomal abnormalitiesAdvanced maternal age |
| spellingShingle | Li-Ping Chen Yong-Feng Lai Xiao-Hong Zhong Jian-Hong You Jiang-Hua Chen Jing-Xian Xie Xiao-Kang Chen Xiao-Yan Chen Guo-Rong Lyu Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age BMC Pregnancy and Childbirth Ultrasonography Fetus Aberrant right subclavian artery Chromosomal abnormalities Advanced maternal age |
| title | Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| title_full | Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| title_fullStr | Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| title_full_unstemmed | Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| title_short | Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| title_sort | predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age |
| topic | Ultrasonography Fetus Aberrant right subclavian artery Chromosomal abnormalities Advanced maternal age |
| url | https://doi.org/10.1186/s12884-021-03626-7 |
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