Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene
Nanoemulsion-based delivery systems can be utilized in functional foods and beverages to improve the bioavailability of nutraceuticals. We determined the influence of carrier oil type on the bioavailability of pterostilbene encapsulated in nanoemulsions containing either flaxseed or olive oil as the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614004095 |
| _version_ | 1818661897575071744 |
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| author | Yue Sun Ziyuan Xia Jinkai Zheng Peiju Qiu Lijuan Zhang David Julian McClements Hang Xiao |
| author_facet | Yue Sun Ziyuan Xia Jinkai Zheng Peiju Qiu Lijuan Zhang David Julian McClements Hang Xiao |
| author_sort | Yue Sun |
| collection | DOAJ |
| description | Nanoemulsion-based delivery systems can be utilized in functional foods and beverages to improve the bioavailability of nutraceuticals. We determined the influence of carrier oil type on the bioavailability of pterostilbene encapsulated in nanoemulsions containing either flaxseed or olive oil as the carrier oil. The nanoemulsions were then subjected to a simulated gastrointestinal tract (mouth, stomach, small intestine), and the resulting micelle phases were used to establish pterostilbene bioavailability using a Caco-2 cell model. Both nanoemulsions significantly enhanced the bioaccessibility of pterostilbene within the micelle phase. However, olive oil nanoemulsions increased trans-enterocyte transport of pterostilbene more effectively than flaxseed oil ones. Moreover, the patterns of metabolism of pterostilbene during its trans-enterocyte transport were dramatically different when pterostilbene was delivered using nanoemulsions with different carrier oil types. |
| first_indexed | 2024-12-17T04:52:21Z |
| format | Article |
| id | doaj.art-e441370734d34741938b6113f7823416 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T04:52:21Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e441370734d34741938b6113f78234162022-12-21T22:02:51ZengElsevierJournal of Functional Foods1756-46462015-03-01136170Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbeneYue Sun0Ziyuan Xia1Jinkai Zheng2Peiju Qiu3Lijuan Zhang4David Julian McClements5Hang Xiao6Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA; School of Pharmacy, Ocean University of China, Qingdao, ChinaDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, USADepartment of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, ChinaDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, USA; School of Pharmacy, Ocean University of China, Qingdao, ChinaSchool of Pharmacy, Ocean University of China, Qingdao, ChinaDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Corresponding author. 102 Holdsworth Way Chenoweth, Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA. Tel.: +1 413 5452281; fax: +1 413 5451262.Nanoemulsion-based delivery systems can be utilized in functional foods and beverages to improve the bioavailability of nutraceuticals. We determined the influence of carrier oil type on the bioavailability of pterostilbene encapsulated in nanoemulsions containing either flaxseed or olive oil as the carrier oil. The nanoemulsions were then subjected to a simulated gastrointestinal tract (mouth, stomach, small intestine), and the resulting micelle phases were used to establish pterostilbene bioavailability using a Caco-2 cell model. Both nanoemulsions significantly enhanced the bioaccessibility of pterostilbene within the micelle phase. However, olive oil nanoemulsions increased trans-enterocyte transport of pterostilbene more effectively than flaxseed oil ones. Moreover, the patterns of metabolism of pterostilbene during its trans-enterocyte transport were dramatically different when pterostilbene was delivered using nanoemulsions with different carrier oil types.http://www.sciencedirect.com/science/article/pii/S1756464614004095NanoemulsionPterostilbeneBioavailabilityMetabolismOlive oilFlaxseed oil |
| spellingShingle | Yue Sun Ziyuan Xia Jinkai Zheng Peiju Qiu Lijuan Zhang David Julian McClements Hang Xiao Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene Journal of Functional Foods Nanoemulsion Pterostilbene Bioavailability Metabolism Olive oil Flaxseed oil |
| title | Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene |
| title_full | Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene |
| title_fullStr | Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene |
| title_full_unstemmed | Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene |
| title_short | Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene |
| title_sort | nanoemulsion based delivery systems for nutraceuticals influence of carrier oil type on bioavailability of pterostilbene |
| topic | Nanoemulsion Pterostilbene Bioavailability Metabolism Olive oil Flaxseed oil |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614004095 |
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