N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is characterized by multiple biological and clinical features. N6-methyladenosine (m6A) modification is the most common type of RNA modifications in eukaryotes and plays an important regulatory rol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223015172 |
| _version_ | 1797630638497464320 |
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| author | Wei Wang Huaili Wang Tongwen Sun |
| author_facet | Wei Wang Huaili Wang Tongwen Sun |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is characterized by multiple biological and clinical features. N6-methyladenosine (m6A) modification is the most common type of RNA modifications in eukaryotes and plays an important regulatory role in various biological processes. Recently, m6A modification has been found to be involved in the regulation of immune responses in sepsis. In addition, several studies have shown that m6A modification is involved in sepsis-induced multiple organ dysfunctions, including cardiovascular dysfunction, acute lung injury (ALI), acute kidney injury (AKI) and etc. Considering the complex pathogenesis of sepsis and the lack of specific therapeutic drugs, m6A modification may be the important bond in the pathophysiological process of sepsis and even therapeutic targets. This review systematically highlights the recent advances regarding the roles of m6A modification in sepsis and sheds light on their use as treatment targets for sepsis. |
| first_indexed | 2024-03-11T11:11:00Z |
| format | Article |
| id | doaj.art-e4413bcabb1b470b83fc4d9b0fe38965 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:11:00Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e4413bcabb1b470b83fc4d9b0fe389652023-11-12T04:39:03ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115719N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsisWei Wang0Huaili Wang1Tongwen Sun2Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China; Corresponding authors.General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care Medicine, Zhengzhou, Henan, China; Corresponding authors.Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is characterized by multiple biological and clinical features. N6-methyladenosine (m6A) modification is the most common type of RNA modifications in eukaryotes and plays an important regulatory role in various biological processes. Recently, m6A modification has been found to be involved in the regulation of immune responses in sepsis. In addition, several studies have shown that m6A modification is involved in sepsis-induced multiple organ dysfunctions, including cardiovascular dysfunction, acute lung injury (ALI), acute kidney injury (AKI) and etc. Considering the complex pathogenesis of sepsis and the lack of specific therapeutic drugs, m6A modification may be the important bond in the pathophysiological process of sepsis and even therapeutic targets. This review systematically highlights the recent advances regarding the roles of m6A modification in sepsis and sheds light on their use as treatment targets for sepsis.http://www.sciencedirect.com/science/article/pii/S0753332223015172SepsisM6AImmune responsePost-transcriptional regulationMultiple organ dysfunction |
| spellingShingle | Wei Wang Huaili Wang Tongwen Sun N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis Biomedicine & Pharmacotherapy Sepsis M6A Immune response Post-transcriptional regulation Multiple organ dysfunction |
| title | N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis |
| title_full | N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis |
| title_fullStr | N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis |
| title_full_unstemmed | N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis |
| title_short | N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis |
| title_sort | n6 methyladenosine modification regulatory mechanisms and therapeutic potential in sepsis |
| topic | Sepsis M6A Immune response Post-transcriptional regulation Multiple organ dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223015172 |
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