Improvement of Aptamer Affinity by Dimerization

Improvement of Aptamer Affinity by Dimerization

To increase the affinities of aptamers for their targets, we designed an aptamerdimer for thrombin and VEGF. This design is based on the avidity of the antibody, whichenables the aptamer to connect easily since it is a single-strand nucleic acid. In this study,we connected a 15-mer thrombin-binding...

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Bibliographic Details
Main Authors: Kazunori Ikebukuro, Koji Sode, Ken-ichi Taira, Hijiri Hasegawa
Format: Article
Language:English
Published: MDPI AG 2008-02-01
Series:Sensors
Subjects:
Aptamer
dimerization
avidity
Online Access:http://www.mdpi.com/1424-8220/8/2/1090/

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