Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Asiatic acid is a triterpenoid compound extracted from a medicinal plant Centella asiatica. It has been used as a highly efficient compound for the treatment of cancer and hyperlipidemia, as well as possessing potential antiinflammatory properties. However, its effects on bone metabolism and osteopo...

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Bibliographic Details
Main Authors: Guoju Hong, Lin Zhou, Xiaorui Han, Ping Sun, Zhenqiu Chen, Wei He, Jennifer Tickner, Leilei Chen, Xuguang Shi, Jiake Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
asiatic acid
osteoclast
RANKL
bone resorption
osteoporosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00331/full

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