Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes
Abstract This study investigated the progression detection capabilities of circumpapillary and macular vessel density (cpVD and mVD) in advanced primary open angle glaucoma (POAG) eyes using the rates of change in VD (trend-based analysis) and variability limits derived from healthy eyes. (event-bas...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16083-9 |
| _version_ | 1818517738490953728 |
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| author | Anna Lee Kyung Rim Sung Joong Won Shin |
| author_facet | Anna Lee Kyung Rim Sung Joong Won Shin |
| author_sort | Anna Lee |
| collection | DOAJ |
| description | Abstract This study investigated the progression detection capabilities of circumpapillary and macular vessel density (cpVD and mVD) in advanced primary open angle glaucoma (POAG) eyes using the rates of change in VD (trend-based analysis) and variability limits derived from healthy eyes. (event-based analysis) This study included 75 POAG eyes [visual field (VF) mean deviation < − 10 decibels, mean follow-up; 2.3 years] and 33 healthy eyes. Of 75 POAG eyes, 17 (22.7 %) and 58 eyes (77.3 %) were classified into the VF progression and stable groups, respectively. The VF progression group showed significantly faster VD loss than the stable group. (cpVD; − 1.76 vs. − 0.84 %/year, mVD; − 1.10 vs. − 0.47 %/year, P < 0.05) However, the rates of change in circumpapillary retinal nerve fiber layer and macular ganglion cell complex thickness were similar between the groups. (cpRNFLT; − 0.67 vs. − 0.53 $$\mu$$ μ m/year, GCCT; − 0.48 vs. − 0.12 $$\mu$$ μ m/year, P > 0.05) Event-based analysis showed stronger agreement between VD and VF progression (cpVD; kappa value (k) = 0.630, mVD; k = 0.667, P < 0.05) than that between structure and VF progression. (cpRNFLT; k = 0.111, GCCT; k = 0.194, P > 0.05). In conclusion, VD loss showed better progression detection capabilities than structural loss in advanced POAG eyes. Detection of cpVD and mVD loss may be useful for detecting progression in the advanced stages of POAG to complement other reference standard strategies. |
| first_indexed | 2024-12-11T01:00:20Z |
| format | Article |
| id | doaj.art-e44454c35c14462b9e037c6c1687c385 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T01:00:20Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e44454c35c14462b9e037c6c1687c3852022-12-22T01:26:21ZengNature PortfolioScientific Reports2045-23222022-07-0112111010.1038/s41598-022-16083-9Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyesAnna Lee0Kyung Rim Sung1Joong Won Shin2Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical CenterDepartment of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical CenterDepartment of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical CenterAbstract This study investigated the progression detection capabilities of circumpapillary and macular vessel density (cpVD and mVD) in advanced primary open angle glaucoma (POAG) eyes using the rates of change in VD (trend-based analysis) and variability limits derived from healthy eyes. (event-based analysis) This study included 75 POAG eyes [visual field (VF) mean deviation < − 10 decibels, mean follow-up; 2.3 years] and 33 healthy eyes. Of 75 POAG eyes, 17 (22.7 %) and 58 eyes (77.3 %) were classified into the VF progression and stable groups, respectively. The VF progression group showed significantly faster VD loss than the stable group. (cpVD; − 1.76 vs. − 0.84 %/year, mVD; − 1.10 vs. − 0.47 %/year, P < 0.05) However, the rates of change in circumpapillary retinal nerve fiber layer and macular ganglion cell complex thickness were similar between the groups. (cpRNFLT; − 0.67 vs. − 0.53 $$\mu$$ μ m/year, GCCT; − 0.48 vs. − 0.12 $$\mu$$ μ m/year, P > 0.05) Event-based analysis showed stronger agreement between VD and VF progression (cpVD; kappa value (k) = 0.630, mVD; k = 0.667, P < 0.05) than that between structure and VF progression. (cpRNFLT; k = 0.111, GCCT; k = 0.194, P > 0.05). In conclusion, VD loss showed better progression detection capabilities than structural loss in advanced POAG eyes. Detection of cpVD and mVD loss may be useful for detecting progression in the advanced stages of POAG to complement other reference standard strategies.https://doi.org/10.1038/s41598-022-16083-9 |
| spellingShingle | Anna Lee Kyung Rim Sung Joong Won Shin Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes Scientific Reports |
| title | Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| title_full | Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| title_fullStr | Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| title_full_unstemmed | Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| title_short | Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| title_sort | progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes |
| url | https://doi.org/10.1038/s41598-022-16083-9 |
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