Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil

Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil

To explore the impact of omecamtiv mecarbil (OM) on the gene expression profile in adult male rats. Fourteen male Wistar rats were randomly assigned to a single OM (1.2 mg/kg/h; n = 6) or placebo (n = 8) 30-min infusion. Echocardiography was performed before and after OM infusion. Seven days after i...

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Bibliographic Details
Main Authors: Bachar El Oumeiri, Laurence Dewachter, Philippe Van de Borne, Géraldine Hubesch, Christian Melot, Pascale Jespers, Constantin Stefanidis, Kathleen Mc Entee, Frédéric Vanden Eynden
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Genes
Subjects:
left ventricle
omecamtiv mecarbil
gene expression
apoptosis
metabolism
oxidative stress
Online Access:https://www.mdpi.com/2073-4425/14/1/122

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