Mutant <i>C. elegans</i> p53 Together with Gain-of-Function GLP-1/Notch Decreases UVC-Damage-Induced Germline Cell Death but Increases PARP Inhibitor-Induced Germline Cell Death

Mutant <i>C. elegans</i> p53 Together with Gain-of-Function GLP-1/Notch Decreases UVC-Damage-Induced Germline Cell Death but Increases PARP Inhibitor-Induced Germline Cell Death

The <i>TP53</i> gene is mutated in over 50% of human cancers, and the <i>C. elegans</i><i>p53-1</i><i>(cep-1)</i> gene encodes the ortholog CEP-1. CEP-1 is activated by ultraviolet type C (UVC)-induced DNA damage and activates genes that induce germlin...

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Bibliographic Details
Main Authors: Jorge Canar, Prima Manandhar-Sasaki, Jill Bargonetti
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
p53
CEP-1
cancer
DNA damage
PARP inhibitor
lifespan
Online Access:https://www.mdpi.com/2072-6694/14/19/4929

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