Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations
Background. A comprehensive integrated study of the human spinal cord in the prenatal period of ontogenesis will make it possible to deepen knowledge about the mechanisms of malformation and increase prognostic data, as well as the likelihood of their correction in utero in early gestation. Objectiv...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2020-10-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://morphology.dma.dp.ua/article/view/219749 |
| _version_ | 1818330281686335488 |
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| author | S. O. Prykhodko V. S. Shkolnikov |
| author_facet | S. O. Prykhodko V. S. Shkolnikov |
| author_sort | S. O. Prykhodko |
| collection | DOAJ |
| description | Background. A comprehensive integrated study of the human spinal cord in the prenatal period of ontogenesis will make it possible to deepen knowledge about the mechanisms of malformation and increase prognostic data, as well as the likelihood of their correction in utero in early gestation. Objective: to establish the characteristic signs of differences in the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis in comparison with fetuses with developmental anomalies. During the study, the following methods were used: anatomical, histological, immunohistochemical, morphometric and statistical. Results. All macrometric parameters of the spinal pulp in the studied malformations are lower than those of their age group. Thus, the parameters of the spinal cord of Siamese twins 17-18 weeks old corresponded to the parameters of fetuses of 14-15 weeks without malformations. In anencephals of 17-18 weeks, the total length corresponded to human fetuses of 11-12 weeks. At the same time, the length and diameter of the cervical and lumbosacral thickenings corresponded to similar parameters of human fetuses of 8-9 weeks. The length of the spinal cord of anencephals of 20-21 weeks actually corresponded to the length of the spinal cord of fetuses of 14-15 weeks, other parameters - 11-12 weeks. In fetuses with spina bifida 17-18 weeks, the length of the spinal cord was 14-15 weeks, the diameter of the thoracic part was 9-10 weeks, the diameter of the lumbosacral thickening was 8-9 weeks. In fetuses with spina bifida of 20-21 weeks, the length of the spinal cord also corresponded to 14-15 weeks, the length and diameter of the cervical and lumbosacral thickenings were similar to those of fetuses of 17-18 weeks. In fetuses with teratomas, the length of the spinal cord corresponded to fetuses of 14-15 weeks. Conclusion. Macrometric parameters of the spinal cord lesions of human fetuses with the above-described congenital anomalies lag behind in development compared with fetuses without malformations of the corresponding age period of ontogenesis. The exception is the fetus of a person with teratomas of 17-18 weeks, where, in addition to the length of the spinal cord, all other parameters correspond to their age group. |
| first_indexed | 2024-12-13T13:01:28Z |
| format | Article |
| id | doaj.art-e448a46611aa428a8ca3e23bb6279432 |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-13T13:01:28Z |
| publishDate | 2020-10-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-e448a46611aa428a8ca3e23bb62794322022-12-21T23:45:00ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652020-10-01143656910.26641/1997-9665.2020.3.65-69219749Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformationsS. O. Prykhodko0V. S. Shkolnikov1Вінницький національний медичний університет ім. М.І. Пирогова, Вінниця, УкраїнаВінницький національний медичний університет ім. М.І. Пирогова, Вінниця, УкраїнаBackground. A comprehensive integrated study of the human spinal cord in the prenatal period of ontogenesis will make it possible to deepen knowledge about the mechanisms of malformation and increase prognostic data, as well as the likelihood of their correction in utero in early gestation. Objective: to establish the characteristic signs of differences in the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis in comparison with fetuses with developmental anomalies. During the study, the following methods were used: anatomical, histological, immunohistochemical, morphometric and statistical. Results. All macrometric parameters of the spinal pulp in the studied malformations are lower than those of their age group. Thus, the parameters of the spinal cord of Siamese twins 17-18 weeks old corresponded to the parameters of fetuses of 14-15 weeks without malformations. In anencephals of 17-18 weeks, the total length corresponded to human fetuses of 11-12 weeks. At the same time, the length and diameter of the cervical and lumbosacral thickenings corresponded to similar parameters of human fetuses of 8-9 weeks. The length of the spinal cord of anencephals of 20-21 weeks actually corresponded to the length of the spinal cord of fetuses of 14-15 weeks, other parameters - 11-12 weeks. In fetuses with spina bifida 17-18 weeks, the length of the spinal cord was 14-15 weeks, the diameter of the thoracic part was 9-10 weeks, the diameter of the lumbosacral thickening was 8-9 weeks. In fetuses with spina bifida of 20-21 weeks, the length of the spinal cord also corresponded to 14-15 weeks, the length and diameter of the cervical and lumbosacral thickenings were similar to those of fetuses of 17-18 weeks. In fetuses with teratomas, the length of the spinal cord corresponded to fetuses of 14-15 weeks. Conclusion. Macrometric parameters of the spinal cord lesions of human fetuses with the above-described congenital anomalies lag behind in development compared with fetuses without malformations of the corresponding age period of ontogenesis. The exception is the fetus of a person with teratomas of 17-18 weeks, where, in addition to the length of the spinal cord, all other parameters correspond to their age group.http://morphology.dma.dp.ua/article/view/219749пренатальний періодспинний мозокмальформаціїмакрометричні параметри |
| spellingShingle | S. O. Prykhodko V. S. Shkolnikov Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations Морфологія пренатальний період спинний мозок мальформації макрометричні параметри |
| title | Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| title_full | Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| title_fullStr | Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| title_full_unstemmed | Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| title_short | Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| title_sort | comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations |
| topic | пренатальний період спинний мозок мальформації макрометричні параметри |
| url | http://morphology.dma.dp.ua/article/view/219749 |
| work_keys_str_mv | AT soprykhodko comparativecharacteristicsofthemacrometricparametersofthehumanspinalcordintheprenatalperiodofontogenesiswithfetuseswithmalformations AT vsshkolnikov comparativecharacteristicsofthemacrometricparametersofthehumanspinalcordintheprenatalperiodofontogenesiswithfetuseswithmalformations |