Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer
Background & Objective: Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA rs2273535 and CDKN1B rs34330 polymorphisms with risk...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fasa University of Medical Sciences
2022-11-01
|
| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-2869-en.pdf |
| _version_ | 1797679591042580480 |
|---|---|
| author | Atefeh Liravi seyed Massoud Houshmand Mojtaba Jafarnia Mohsen Forouzanfar |
| author_facet | Atefeh Liravi seyed Massoud Houshmand Mojtaba Jafarnia Mohsen Forouzanfar |
| author_sort | Atefeh Liravi |
| collection | DOAJ |
| description | Background & Objective: Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA rs2273535 and CDKN1B rs34330 polymorphisms with risk of female breast cancer in southwest part of Iran.
Materials & Methods: This case-control study was done on 50 women with breast cancer and 50 healthy women without any symptoms or family history of breast cancer as the case and control group, respectively. Restriction fragment length polymorphism (RFLP- PCR) technique was designed to determine the AURKA rs2273535 and CDKN1B rs34330 gene polymorphisms. Afterwards, statistical analysis was done by means of SPSS (version 17).
Results: In current research, our finding showed that rs2273535 T allele increased the susceptibility of breast cancer (OR:2.58, 95%CI:1.5-31.09, P=0.006). Moreover, T allele in dominant phase could raise the risk of the breast cancer (OR:3.01, 65%CI:1.31-6.92, P=0.009). However, the other polymorphism, CDKN1B rs34330, revealed no associations with increased risk of breast cancer.
Conclusion: These findings suggest that AURKA rs2273535 may influence individual’s susceptibility to breast cancer. But we found no associations regarding CDKN1B rs34330 polymorphism and this type of cancer. |
| first_indexed | 2024-03-11T23:17:01Z |
| format | Article |
| id | doaj.art-e44b03a9d7c9433cac72d94426eb92b0 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:01Z |
| publishDate | 2022-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-e44b03a9d7c9433cac72d94426eb92b02023-09-20T21:29:47ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232022-11-01124422430Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast CancerAtefeh Liravi0seyed Massoud Houshmand1Mojtaba Jafarnia2Mohsen Forouzanfar3 Department of Genetic, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Department of Medical Genetic, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Department of Genetic, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Background & Objective: Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA rs2273535 and CDKN1B rs34330 polymorphisms with risk of female breast cancer in southwest part of Iran. Materials & Methods: This case-control study was done on 50 women with breast cancer and 50 healthy women without any symptoms or family history of breast cancer as the case and control group, respectively. Restriction fragment length polymorphism (RFLP- PCR) technique was designed to determine the AURKA rs2273535 and CDKN1B rs34330 gene polymorphisms. Afterwards, statistical analysis was done by means of SPSS (version 17). Results: In current research, our finding showed that rs2273535 T allele increased the susceptibility of breast cancer (OR:2.58, 95%CI:1.5-31.09, P=0.006). Moreover, T allele in dominant phase could raise the risk of the breast cancer (OR:3.01, 65%CI:1.31-6.92, P=0.009). However, the other polymorphism, CDKN1B rs34330, revealed no associations with increased risk of breast cancer. Conclusion: These findings suggest that AURKA rs2273535 may influence individual’s susceptibility to breast cancer. But we found no associations regarding CDKN1B rs34330 polymorphism and this type of cancer.http://jabs.fums.ac.ir/article-1-2869-en.pdfbreast canceraurkacdkn1brs2273535rs34330rflp |
| spellingShingle | Atefeh Liravi seyed Massoud Houshmand Mojtaba Jafarnia Mohsen Forouzanfar Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer Journal of Advanced Biomedical Sciences breast cancer aurka cdkn1b rs2273535 rs34330 rflp |
| title | Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer |
| title_full | Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer |
| title_fullStr | Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer |
| title_full_unstemmed | Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer |
| title_short | Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer |
| title_sort | evaluation of aurka rs2273535 and cdkn1b rs34330 polymorphisms association with the risk of breast cancer |
| topic | breast cancer aurka cdkn1b rs2273535 rs34330 rflp |
| url | http://jabs.fums.ac.ir/article-1-2869-en.pdf |
| work_keys_str_mv | AT atefehliravi evaluationofaurkars2273535andcdkn1brs34330polymorphismsassociationwiththeriskofbreastcancer AT seyedmassoudhoushmand evaluationofaurkars2273535andcdkn1brs34330polymorphismsassociationwiththeriskofbreastcancer AT mojtabajafarnia evaluationofaurkars2273535andcdkn1brs34330polymorphismsassociationwiththeriskofbreastcancer AT mohsenforouzanfar evaluationofaurkars2273535andcdkn1brs34330polymorphismsassociationwiththeriskofbreastcancer |