3-(3-Bromophenyl)-7-acetoxycoumarin
In natural product synthesis, the procurement of easily accessible starting materials is crucial. Chromenones and their subclass, coumarins, are a wide family of small, oxygen-containing aromatic heterocycles. Phenylcoumarins offer a particularly excellent starting point for a diverse chemical space...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2022/4/M1513 |
| _version_ | 1827637637008064512 |
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| author | Petri A. Turhanen Liisa P. Nousiainen Juri M. Timonen |
| author_facet | Petri A. Turhanen Liisa P. Nousiainen Juri M. Timonen |
| author_sort | Petri A. Turhanen |
| collection | DOAJ |
| description | In natural product synthesis, the procurement of easily accessible starting materials is crucial. Chromenones and their subclass, coumarins, are a wide family of small, oxygen-containing aromatic heterocycles. Phenylcoumarins offer a particularly excellent starting point for a diverse chemical space of natural products, and thus are excellent staring materials for more complex natural products. Herein, we report an efficient synthesis of an easily accessible 3-phenylcoumarin bearing two orthogonally substitutable groups, bromine, and an acetyl-protected phenylic hydroxyl group. |
| first_indexed | 2024-03-09T16:03:41Z |
| format | Article |
| id | doaj.art-e44be3732c664c4cb773a30856f8042d |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-09T16:03:41Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-e44be3732c664c4cb773a30856f8042d2023-11-24T16:54:34ZengMDPI AGMolbank1422-85992022-12-0120224M151310.3390/M15133-(3-Bromophenyl)-7-acetoxycoumarinPetri A. Turhanen0Liisa P. Nousiainen1Juri M. Timonen2School of Pharmacy, Faculty of Health Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, FinlandInstitute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, FinlandSchool of Pharmacy, Faculty of Health Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, FinlandIn natural product synthesis, the procurement of easily accessible starting materials is crucial. Chromenones and their subclass, coumarins, are a wide family of small, oxygen-containing aromatic heterocycles. Phenylcoumarins offer a particularly excellent starting point for a diverse chemical space of natural products, and thus are excellent staring materials for more complex natural products. Herein, we report an efficient synthesis of an easily accessible 3-phenylcoumarin bearing two orthogonally substitutable groups, bromine, and an acetyl-protected phenylic hydroxyl group.https://www.mdpi.com/1422-8599/2022/4/M1513coumarinchromenonenatural product synthesismicrowave |
| spellingShingle | Petri A. Turhanen Liisa P. Nousiainen Juri M. Timonen 3-(3-Bromophenyl)-7-acetoxycoumarin Molbank coumarin chromenone natural product synthesis microwave |
| title | 3-(3-Bromophenyl)-7-acetoxycoumarin |
| title_full | 3-(3-Bromophenyl)-7-acetoxycoumarin |
| title_fullStr | 3-(3-Bromophenyl)-7-acetoxycoumarin |
| title_full_unstemmed | 3-(3-Bromophenyl)-7-acetoxycoumarin |
| title_short | 3-(3-Bromophenyl)-7-acetoxycoumarin |
| title_sort | 3 3 bromophenyl 7 acetoxycoumarin |
| topic | coumarin chromenone natural product synthesis microwave |
| url | https://www.mdpi.com/1422-8599/2022/4/M1513 |
| work_keys_str_mv | AT petriaturhanen 33bromophenyl7acetoxycoumarin AT liisapnousiainen 33bromophenyl7acetoxycoumarin AT jurimtimonen 33bromophenyl7acetoxycoumarin |