Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones
Two approaches to studying the origin and transmission mechanism of the flea-borne plague pathogen, Yersinia pestis: molecular-genetic and ecological ones – are considered in this review. The molecular genetic approach is based on saltation evolutionary ideology and relies upon the phenomenon of hor...
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2018-07-01
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| Series: | Проблемы особо опасных инфекций |
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| Online Access: | https://journal.microbe.ru/jour/article/view/477 |
| _version_ | 1797220836264902656 |
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| author | V. V. Suntsov |
| author_facet | V. V. Suntsov |
| author_sort | V. V. Suntsov |
| collection | DOAJ |
| description | Two approaches to studying the origin and transmission mechanism of the flea-borne plague pathogen, Yersinia pestis: molecular-genetic and ecological ones – are considered in this review. The molecular genetic approach is based on saltation evolutionary ideology and relies upon the phenomenon of horizontal gene transfer of pla and ymt as critical evolutionary events. Further deletion of some structural and regulatory genes optimized “blockage” mechanism of transmission. The Ecological approach is based on the modern synthetic theory of evolution. It posits a gradual population-genetic transformation in the Marmot – Flea (Marmota sibirica – Oropsylla silantiewi) transitional (heterothermal, heteroimmune) host-parasite system in Late Pleistocene – Holocene epochs. The best prospects for disclosing the mechanisms of evolutionary formation of flea-borne Y. pestis transmission consist in the synthesis of molecular-genetic and ecological approaches. |
| first_indexed | 2024-03-08T13:42:57Z |
| format | Article |
| id | doaj.art-e44c7ac0b3fa450b8ba78fa8e91b08b8 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:55:52Z |
| publishDate | 2018-07-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-e44c7ac0b3fa450b8ba78fa8e91b08b82024-04-05T16:47:13ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2018-07-0102374410.21055/0370-1069-2018-2-37-44466Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological OnesV. V. Suntsov0A.N.Severtsev Institute of Ecology and Evolution Problems, MoscowTwo approaches to studying the origin and transmission mechanism of the flea-borne plague pathogen, Yersinia pestis: molecular-genetic and ecological ones – are considered in this review. The molecular genetic approach is based on saltation evolutionary ideology and relies upon the phenomenon of horizontal gene transfer of pla and ymt as critical evolutionary events. Further deletion of some structural and regulatory genes optimized “blockage” mechanism of transmission. The Ecological approach is based on the modern synthetic theory of evolution. It posits a gradual population-genetic transformation in the Marmot – Flea (Marmota sibirica – Oropsylla silantiewi) transitional (heterothermal, heteroimmune) host-parasite system in Late Pleistocene – Holocene epochs. The best prospects for disclosing the mechanisms of evolutionary formation of flea-borne Y. pestis transmission consist in the synthesis of molecular-genetic and ecological approaches.https://journal.microbe.ru/jour/article/view/477horizontal gene transferadaptation-genesisyersinia pseudotuberculosisy. pestismarmota sibiricaoropsylla silantiewimechanical transmissionbiological transmissionsartan cooling |
| spellingShingle | V. V. Suntsov Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones Проблемы особо опасных инфекций horizontal gene transfer adaptation-genesis yersinia pseudotuberculosis y. pestis marmota sibirica oropsylla silantiewi mechanical transmission biological transmission sartan cooling |
| title | Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones |
| title_full | Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones |
| title_fullStr | Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones |
| title_full_unstemmed | Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones |
| title_short | Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones |
| title_sort | genesis of flea born transmission of plague microbe yersinia pestis two approachs molecular genetic and ecological ones |
| topic | horizontal gene transfer adaptation-genesis yersinia pseudotuberculosis y. pestis marmota sibirica oropsylla silantiewi mechanical transmission biological transmission sartan cooling |
| url | https://journal.microbe.ru/jour/article/view/477 |
| work_keys_str_mv | AT vvsuntsov genesisoffleaborntransmissionofplaguemicrobeyersiniapestistwoapproachsmoleculargeneticandecologicalones |