A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea
Influenza affects all age groups, but the risk of hospitalization and death due to influenza is strongly age-related and is at its highest among the elderly aged 65 years and older. The objective of this study is to compare the differences in influenza-associated disease burden under three different...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1387 |
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| author | Min Joo Choi Jae-Won Yun Joon Young Song Karam Ko Joaquin F. Mould Hee Jin Cheong |
| author_facet | Min Joo Choi Jae-Won Yun Joon Young Song Karam Ko Joaquin F. Mould Hee Jin Cheong |
| author_sort | Min Joo Choi |
| collection | DOAJ |
| description | Influenza affects all age groups, but the risk of hospitalization and death due to influenza is strongly age-related and is at its highest among the elderly aged 65 years and older. The objective of this study is to compare the differences in influenza-associated disease burden under three different influenza vaccination strategies—the standard-dose quadrivalent influenza vaccine (QIV), high-dose QIV (HD-QIV), and MF59<sup>®</sup>-adjuvanted QIV (aQIV)—for the elderly population aged 65 years and older in South Korea. A one-year decision-tree model was developed to compare influenza disease burdens. The input data for the model were obtained from published literature reviews and surveillance data from the Korea Disease Control and Prevention Agency (KDCA). The analysis indicated that aQIV is more effective than QIV, preventing 35,390 influenza cases, 1602 influenza-associated complications, 709 influenza-associated hospitalizations, and 145 influenza-associated deaths annually. Additionally, aQIV, when compared to HD-QIV, also reduced the influenza-associated burden of disease, preventing 7247 influenza cases, 328 influenza-associated complications, 145 influenza-associated hospitalizations, and 30 influenza-associated deaths annually. Switching the vaccination strategy from QIV to aQIV is predicted to reduce the influenza-associated disease burden for the elderly in South Korea. The public health gains from aQIV and HD-QIV are expected to be comparable. Future studies comparing the effectiveness of the vaccines will further inform future vaccination strategies for the elderly in South Korea. |
| first_indexed | 2024-03-09T22:17:42Z |
| format | Article |
| id | doaj.art-e450d35810084c0092f98a065f2b1508 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:42Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e450d35810084c0092f98a065f2b15082023-11-23T19:20:11ZengMDPI AGVaccines2076-393X2022-08-01109138710.3390/vaccines10091387A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South KoreaMin Joo Choi0Jae-Won Yun1Joon Young Song2Karam Ko3Joaquin F. Mould4Hee Jin Cheong5Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, KoreaAsia Pacific Influenza Institute, Korea University College of Medicine, Seoul 08308, KoreaAsia Pacific Influenza Institute, Korea University College of Medicine, Seoul 08308, KoreaSeqirus Korea Ltd., Seoul 03157, KoreaSeqirus USA Inc., Summit, NJ 07901, USAAsia Pacific Influenza Institute, Korea University College of Medicine, Seoul 08308, KoreaInfluenza affects all age groups, but the risk of hospitalization and death due to influenza is strongly age-related and is at its highest among the elderly aged 65 years and older. The objective of this study is to compare the differences in influenza-associated disease burden under three different influenza vaccination strategies—the standard-dose quadrivalent influenza vaccine (QIV), high-dose QIV (HD-QIV), and MF59<sup>®</sup>-adjuvanted QIV (aQIV)—for the elderly population aged 65 years and older in South Korea. A one-year decision-tree model was developed to compare influenza disease burdens. The input data for the model were obtained from published literature reviews and surveillance data from the Korea Disease Control and Prevention Agency (KDCA). The analysis indicated that aQIV is more effective than QIV, preventing 35,390 influenza cases, 1602 influenza-associated complications, 709 influenza-associated hospitalizations, and 145 influenza-associated deaths annually. Additionally, aQIV, when compared to HD-QIV, also reduced the influenza-associated burden of disease, preventing 7247 influenza cases, 328 influenza-associated complications, 145 influenza-associated hospitalizations, and 30 influenza-associated deaths annually. Switching the vaccination strategy from QIV to aQIV is predicted to reduce the influenza-associated disease burden for the elderly in South Korea. The public health gains from aQIV and HD-QIV are expected to be comparable. Future studies comparing the effectiveness of the vaccines will further inform future vaccination strategies for the elderly in South Korea.https://www.mdpi.com/2076-393X/10/9/1387influenzadisease burdenaverted outcomesquadrivalent vaccineelderly |
| spellingShingle | Min Joo Choi Jae-Won Yun Joon Young Song Karam Ko Joaquin F. Mould Hee Jin Cheong A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea Vaccines influenza disease burden averted outcomes quadrivalent vaccine elderly |
| title | A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea |
| title_full | A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea |
| title_fullStr | A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea |
| title_full_unstemmed | A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea |
| title_short | A Comparative Analysis of Influenza-Associated Disease Burden with Different Influenza Vaccination Strategies for the Elderly Population in South Korea |
| title_sort | comparative analysis of influenza associated disease burden with different influenza vaccination strategies for the elderly population in south korea |
| topic | influenza disease burden averted outcomes quadrivalent vaccine elderly |
| url | https://www.mdpi.com/2076-393X/10/9/1387 |
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