Sympathetic nervous system and cardiovascular risk in mitral valve prolapse
Mitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and become malignant. Dysregulation of autonomic nervous system - especially sympathetic overdrive – is one of the factors considered to play a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-08-01
|
| Series: | Acta Medica Martiniana |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acm-2019-0007 |
| _version_ | 1797778408900395008 |
|---|---|
| author | Bona Olexova L Mestanik M Jurko A Sekaninova N Slavikova M Tonhajzerova I |
| author_facet | Bona Olexova L Mestanik M Jurko A Sekaninova N Slavikova M Tonhajzerova I |
| author_sort | Bona Olexova L |
| collection | DOAJ |
| description | Mitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and become malignant. Dysregulation of autonomic nervous system - especially sympathetic overdrive – is one of the factors considered to play a key role in its aetiology and development. There is a growing evidence of a large impact of sympathetic system on the development of MVP. Exaggerated sympathetic activity may lead to morphologic changes in valves tissue such as thickening and redundancy. Nowadays, few investigative methods are known for evaluation of the regulatory state of sympathetic nervous system, which could be, theoretically, used to identify the subjects with sympathetic overactivity associated with an increased cardiovascular risk. Electrodermal activity or blood pressure variability represent promising non-invasive methods for evaluation of the regulatory outputs of sympathetic nervous system. There is a possibility to extend a set of investigative methods in MVP and include the monitoring of sympathetic activity in the assessment of cardiovascular risk. This article summarizes knowledge about pathogenesis, diagnostic and therapeutical approaches of MVP, and brings some novel insights on the parameters of autonomic nervous regulation, which haven’t yet been used in cardiovascular risk assessment in MVP. |
| first_indexed | 2024-03-12T23:16:55Z |
| format | Article |
| id | doaj.art-e45140fcff8d4999be060dd896aae4ec |
| institution | Directory Open Access Journal |
| issn | 1338-4139 |
| language | English |
| last_indexed | 2024-03-12T23:16:55Z |
| publishDate | 2019-08-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Martiniana |
| spelling | doaj.art-e45140fcff8d4999be060dd896aae4ec2023-07-17T05:26:04ZengSciendoActa Medica Martiniana1338-41392019-08-01192515710.2478/acm-2019-0007acm-2019-0007Sympathetic nervous system and cardiovascular risk in mitral valve prolapseBona Olexova L0Mestanik M1Jurko A2Sekaninova N3Slavikova M4Tonhajzerova I5Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicPediatric Cardiology, Martin, Slovak RepublicDepartment of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicDepartment of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicDepartment of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicMitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and become malignant. Dysregulation of autonomic nervous system - especially sympathetic overdrive – is one of the factors considered to play a key role in its aetiology and development. There is a growing evidence of a large impact of sympathetic system on the development of MVP. Exaggerated sympathetic activity may lead to morphologic changes in valves tissue such as thickening and redundancy. Nowadays, few investigative methods are known for evaluation of the regulatory state of sympathetic nervous system, which could be, theoretically, used to identify the subjects with sympathetic overactivity associated with an increased cardiovascular risk. Electrodermal activity or blood pressure variability represent promising non-invasive methods for evaluation of the regulatory outputs of sympathetic nervous system. There is a possibility to extend a set of investigative methods in MVP and include the monitoring of sympathetic activity in the assessment of cardiovascular risk. This article summarizes knowledge about pathogenesis, diagnostic and therapeutical approaches of MVP, and brings some novel insights on the parameters of autonomic nervous regulation, which haven’t yet been used in cardiovascular risk assessment in MVP.https://doi.org/10.2478/acm-2019-0007mitral valve prolapsecardiovascular risksympathetic nervous systemelectrodermal activityblood pressure variability |
| spellingShingle | Bona Olexova L Mestanik M Jurko A Sekaninova N Slavikova M Tonhajzerova I Sympathetic nervous system and cardiovascular risk in mitral valve prolapse Acta Medica Martiniana mitral valve prolapse cardiovascular risk sympathetic nervous system electrodermal activity blood pressure variability |
| title | Sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| title_full | Sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| title_fullStr | Sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| title_full_unstemmed | Sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| title_short | Sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| title_sort | sympathetic nervous system and cardiovascular risk in mitral valve prolapse |
| topic | mitral valve prolapse cardiovascular risk sympathetic nervous system electrodermal activity blood pressure variability |
| url | https://doi.org/10.2478/acm-2019-0007 |
| work_keys_str_mv | AT bonaolexoval sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse AT mestanikm sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse AT jurkoa sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse AT sekaninovan sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse AT slavikovam sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse AT tonhajzerovai sympatheticnervoussystemandcardiovascularriskinmitralvalveprolapse |