Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review
Thrombotic microangiopathy (TMA) is associated with both hypertensive emergency and primary thrombocytopenia purpura (TTP). However, their clinical management is vastly different, with the latter necessitating urgent plasma exchange (PEX). We report two cases of hypertension-associated TMA (HTN-TMA)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/1880 |
| _version_ | 1797212462846574592 |
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| author | Yang Song Shi Yan Lee Yen-Lin Chee Wei-Ying Jen |
| author_facet | Yang Song Shi Yan Lee Yen-Lin Chee Wei-Ying Jen |
| author_sort | Yang Song |
| collection | DOAJ |
| description | Thrombotic microangiopathy (TMA) is associated with both hypertensive emergency and primary thrombocytopenia purpura (TTP). However, their clinical management is vastly different, with the latter necessitating urgent plasma exchange (PEX). We report two cases of hypertension-associated TMA (HTN-TMA) and a literature review of the clinical management of malignant hypertension. We suggest that in patients presenting with hypertensive emergency associated with TMA, a clinical diagnosis of HTN-TMA should be made, with emergent treatment to lower blood pressure started immediately. Although TTP is a differential diagnosis for TMA, PEX should not be started concurrently in the absence of other supporting evidence for TTP. |
| first_indexed | 2024-04-24T10:42:46Z |
| format | Article |
| id | doaj.art-e453157162c4463f8f2d5d54979746d3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:42:46Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e453157162c4463f8f2d5d54979746d32024-04-12T13:20:55ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137188010.3390/jcm13071880Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature ReviewYang Song0Shi Yan Lee1Yen-Lin Chee2Wei-Ying Jen3Department of Haematology-Oncology, National University Cancer Institute, Singapore 119074, SingaporeDivision of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore 119074, SingaporeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore 119074, SingaporeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore 119074, SingaporeThrombotic microangiopathy (TMA) is associated with both hypertensive emergency and primary thrombocytopenia purpura (TTP). However, their clinical management is vastly different, with the latter necessitating urgent plasma exchange (PEX). We report two cases of hypertension-associated TMA (HTN-TMA) and a literature review of the clinical management of malignant hypertension. We suggest that in patients presenting with hypertensive emergency associated with TMA, a clinical diagnosis of HTN-TMA should be made, with emergent treatment to lower blood pressure started immediately. Although TTP is a differential diagnosis for TMA, PEX should not be started concurrently in the absence of other supporting evidence for TTP.https://www.mdpi.com/2077-0383/13/7/1880TTPMAHAplasma exchangethrombotic microangiopathyhypertensive emergencythrombotic thrombocytopenia purpura |
| spellingShingle | Yang Song Shi Yan Lee Yen-Lin Chee Wei-Ying Jen Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review Journal of Clinical Medicine TTP MAHA plasma exchange thrombotic microangiopathy hypertensive emergency thrombotic thrombocytopenia purpura |
| title | Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review |
| title_full | Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review |
| title_fullStr | Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review |
| title_full_unstemmed | Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review |
| title_short | Hypertensive Emergency with Thrombotic Microangiopathy or TTP? A Case Series and Literature Review |
| title_sort | hypertensive emergency with thrombotic microangiopathy or ttp a case series and literature review |
| topic | TTP MAHA plasma exchange thrombotic microangiopathy hypertensive emergency thrombotic thrombocytopenia purpura |
| url | https://www.mdpi.com/2077-0383/13/7/1880 |
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