Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review
At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. Chloroquine and hydroxychloroquine, typically...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2020.00252/full |
| _version_ | 1819049165866401792 |
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| author | Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Anand V. Kasbekar Anand V. Kasbekar Anand V. Kasbekar David M. Baguley David M. Baguley David M. Baguley |
| author_facet | Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Anand V. Kasbekar Anand V. Kasbekar Anand V. Kasbekar David M. Baguley David M. Baguley David M. Baguley |
| author_sort | Pattarawadee Prayuenyong |
| collection | DOAJ |
| description | At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. Chloroquine and hydroxychloroquine, typically used for the treatment of malaria and autoimmune diseases, have been considered for off-label use in several countries. In the literature, there are reports of ototoxic effects of the drugs causing damage to the inner ear structures, which then result in hearing loss, tinnitus, and/or imbalance. This mini-review represents a summary of the findings from a systematic search regarding ototoxicity of chloroquine and hydroxychloroquine in the published literature. The characteristics of sensorineural hearing loss and/or tinnitus after chloroquine or hydroxychloroquine treatment can be temporary but reports of persistent auditory and vestibular dysfunction exist. These are not frequent, but the impact can be substantial. Additionally, abnormal cochleovestibular development in the newborn was also reported after chloroquine treatment in pregnant women. The suggested dose of chloroquine for COVID-19 infection is considerably higher than the usual dosage for malaria treatment; therefore, it is plausible that the ototoxic effects will be greater. There are potential implications from this review for survivors of COVID-19 treated with chloroquine or hydroxychloroquine. Patient reports of hearing loss, tinnitus, or imbalance should be noted. Those with troublesome hearing loss, tinnitus and/or imbalance are encouraged to be referred for hearing evaluation and interventions once they are stable. Clinical trials of chloroquine or hydroxychloroquine should also consider including audiological monitoring in the protocol. |
| first_indexed | 2024-12-21T11:27:49Z |
| format | Article |
| id | doaj.art-e4545ae4630541d0a5b9163826e1f769 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-21T11:27:49Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-e4545ae4630541d0a5b9163826e1f7692022-12-21T19:05:37ZengFrontiers Media S.A.Frontiers in Public Health2296-25652020-05-01810.3389/fpubh.2020.00252556540Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-ReviewPattarawadee Prayuenyong0Pattarawadee Prayuenyong1Pattarawadee Prayuenyong2Pattarawadee Prayuenyong3Anand V. Kasbekar4Anand V. Kasbekar5Anand V. Kasbekar6David M. Baguley7David M. Baguley8David M. Baguley9Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United KingdomNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United KingdomDepartment of Otorhinolaryngology, Nottingham University Hospitals NHS Trust, Nottingham, United KingdomDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandHearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United KingdomNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United KingdomDepartment of Otorhinolaryngology, Nottingham University Hospitals NHS Trust, Nottingham, United KingdomHearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United KingdomNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United KingdomDepartment of Otorhinolaryngology, Nottingham University Hospitals NHS Trust, Nottingham, United KingdomAt this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. Chloroquine and hydroxychloroquine, typically used for the treatment of malaria and autoimmune diseases, have been considered for off-label use in several countries. In the literature, there are reports of ototoxic effects of the drugs causing damage to the inner ear structures, which then result in hearing loss, tinnitus, and/or imbalance. This mini-review represents a summary of the findings from a systematic search regarding ototoxicity of chloroquine and hydroxychloroquine in the published literature. The characteristics of sensorineural hearing loss and/or tinnitus after chloroquine or hydroxychloroquine treatment can be temporary but reports of persistent auditory and vestibular dysfunction exist. These are not frequent, but the impact can be substantial. Additionally, abnormal cochleovestibular development in the newborn was also reported after chloroquine treatment in pregnant women. The suggested dose of chloroquine for COVID-19 infection is considerably higher than the usual dosage for malaria treatment; therefore, it is plausible that the ototoxic effects will be greater. There are potential implications from this review for survivors of COVID-19 treated with chloroquine or hydroxychloroquine. Patient reports of hearing loss, tinnitus, or imbalance should be noted. Those with troublesome hearing loss, tinnitus and/or imbalance are encouraged to be referred for hearing evaluation and interventions once they are stable. Clinical trials of chloroquine or hydroxychloroquine should also consider including audiological monitoring in the protocol.https://www.frontiersin.org/article/10.3389/fpubh.2020.00252/fullchloroquinehydroxychloroquineototoxicityhearing losstinnitusCOVID-19 |
| spellingShingle | Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Pattarawadee Prayuenyong Anand V. Kasbekar Anand V. Kasbekar Anand V. Kasbekar David M. Baguley David M. Baguley David M. Baguley Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review Frontiers in Public Health chloroquine hydroxychloroquine ototoxicity hearing loss tinnitus COVID-19 |
| title | Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review |
| title_full | Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review |
| title_fullStr | Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review |
| title_full_unstemmed | Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review |
| title_short | Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review |
| title_sort | clinical implications of chloroquine and hydroxychloroquine ototoxicity for covid 19 treatment a mini review |
| topic | chloroquine hydroxychloroquine ototoxicity hearing loss tinnitus COVID-19 |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2020.00252/full |
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