Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease
A 71 year-old woman presented to our hospital with acute onset of progressive cognitive impairment and psychotic symptoms. Five weeks earlier, she noticed memory impairment and diplopia. After two weeks, she was admitted to a psychiatric hospital due to delusions, agitation and hallucinations. After...
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2015-12-01
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| Series: | Clinical and Biomedical Research |
| Subjects: | |
| Online Access: | http://seer.ufrgs.br/index.php/hcpa/article/view/58933 |
| _version_ | 1819174868427472896 |
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| author | Leonardo Cordenonzi Pedroso de Albuquerque Juliana Avila Duarte Artur Francisco Schumacher Schuh |
| author_facet | Leonardo Cordenonzi Pedroso de Albuquerque Juliana Avila Duarte Artur Francisco Schumacher Schuh |
| author_sort | Leonardo Cordenonzi Pedroso de Albuquerque |
| collection | DOAJ |
| description | A 71 year-old woman presented to our hospital with acute onset of progressive cognitive impairment and psychotic symptoms. Five weeks earlier, she noticed memory impairment and diplopia. After two weeks, she was admitted to a psychiatric hospital due to delusions, agitation and hallucinations. After three weeks, she was referred to our hospital with progressive deterioration, especially impairment of language and gait. At admission, examination showed aphasia, myoclonic jerks, apraxic gait and Babinski’s sign.
Laboratory tests showed mild elevation in anti-TPO titer. Other laboratory studies were normal. EEG showed a semi-periodic pattern of widespread sharp-wave discharges with periods of an arrhythmic widespread theta waves. Brain magnetic resonance imaging (MRI) showed hyperintensity on FLAIR and decreased diffusivity in the basal ganglia, specially in the head of caudate and putamen, as well as in the cortex of frontal lobes bilaterally, left parietal lobe and bilateral occipital lobes on diffusion weighted images (DWI) and apparent diffusion map (ADC). There was no gadolinium enhancement. Diagnosis of probable Creutzfeldt-Jakob disease was made. |
| first_indexed | 2024-12-22T20:45:49Z |
| format | Article |
| id | doaj.art-e45693f2a53a474cab3c9627548569b3 |
| institution | Directory Open Access Journal |
| issn | 0101-5575 2357-9730 |
| language | English |
| last_indexed | 2024-12-22T20:45:49Z |
| publishDate | 2015-12-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-e45693f2a53a474cab3c9627548569b32022-12-21T18:13:14ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research0101-55752357-97302015-12-0135428769Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob diseaseLeonardo Cordenonzi Pedroso de Albuquerque0Juliana Avila DuarteArtur Francisco Schumacher Schuh1HCPAHCPAA 71 year-old woman presented to our hospital with acute onset of progressive cognitive impairment and psychotic symptoms. Five weeks earlier, she noticed memory impairment and diplopia. After two weeks, she was admitted to a psychiatric hospital due to delusions, agitation and hallucinations. After three weeks, she was referred to our hospital with progressive deterioration, especially impairment of language and gait. At admission, examination showed aphasia, myoclonic jerks, apraxic gait and Babinski’s sign. Laboratory tests showed mild elevation in anti-TPO titer. Other laboratory studies were normal. EEG showed a semi-periodic pattern of widespread sharp-wave discharges with periods of an arrhythmic widespread theta waves. Brain magnetic resonance imaging (MRI) showed hyperintensity on FLAIR and decreased diffusivity in the basal ganglia, specially in the head of caudate and putamen, as well as in the cortex of frontal lobes bilaterally, left parietal lobe and bilateral occipital lobes on diffusion weighted images (DWI) and apparent diffusion map (ADC). There was no gadolinium enhancement. Diagnosis of probable Creutzfeldt-Jakob disease was made.http://seer.ufrgs.br/index.php/hcpa/article/view/58933Creutzfeldt Jakob disease, MRI, Dementia, Prion |
| spellingShingle | Leonardo Cordenonzi Pedroso de Albuquerque Juliana Avila Duarte Artur Francisco Schumacher Schuh Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease Clinical and Biomedical Research Creutzfeldt Jakob disease, MRI, Dementia, Prion |
| title | Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease |
| title_full | Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease |
| title_fullStr | Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease |
| title_full_unstemmed | Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease |
| title_short | Contribution of magnetic nuclear resonance to the diagnosis of Creutzfeldt-Jakob disease |
| title_sort | contribution of magnetic nuclear resonance to the diagnosis of creutzfeldt jakob disease |
| topic | Creutzfeldt Jakob disease, MRI, Dementia, Prion |
| url | http://seer.ufrgs.br/index.php/hcpa/article/view/58933 |
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