Characterization of a mGluR5 Knockout Rat Model with Hallmarks of Fragile X Syndrome

Characterization of a mGluR5 Knockout Rat Model with Hallmarks of Fragile X Syndrome

The number of reported cases of neurodevelopmental disorders has increased significantly in the last few decades, but the etiology of these diseases remains poorly understood. There is evidence of a fundamental link between genetic abnormalities and symptoms of autism spectrum disorders (ASDs), and...

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Bibliographic Details
Main Authors: Victoria Dahl, Hawley Helmbrecht, Ana Rios Sigler, Kate Hildahl, Holly Sullivan, Sanjana Janakiraman, Saahiti Jasti, Elizabeth Nance
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Life
Subjects:
neuroinflammation
microglia
autism spectrum disorders (ASDs)
neurodevelopmental disorders
extracellular matrix
machine learning
Online Access:https://www.mdpi.com/2075-1729/12/9/1308

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