A case of Dapsone Induced Methemoglobinemia
Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Journal of Pharmaceutical Policy and Practice |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/s40545-019-0185-y |
| _version_ | 1797401311866519552 |
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| author | Najia Mahmood Mutti Ullah Khan Ihtisham U. L. Haq Farhat Afshan Jelani Aayesha Tariq |
| author_facet | Najia Mahmood Mutti Ullah Khan Ihtisham U. L. Haq Farhat Afshan Jelani Aayesha Tariq |
| author_sort | Najia Mahmood |
| collection | DOAJ |
| description | Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO2 and cardio-respiratory status. If left untreated, the disease can be fatal. |
| first_indexed | 2024-03-09T02:08:07Z |
| format | Article |
| id | doaj.art-e457079e437e4eea919c1f76e23c117a |
| institution | Directory Open Access Journal |
| issn | 2052-3211 |
| language | English |
| last_indexed | 2024-03-09T02:08:07Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Pharmaceutical Policy and Practice |
| spelling | doaj.art-e457079e437e4eea919c1f76e23c117a2023-12-07T15:28:02ZengTaylor & Francis GroupJournal of Pharmaceutical Policy and Practice2052-32112019-12-0112110.1186/s40545-019-0185-y12315111A case of Dapsone Induced MethemoglobinemiaNajia Mahmood0Mutti Ullah Khan1Ihtisham U. L. Haq2Farhat Afshan Jelani3Aayesha Tariq4FCPS Medicine, Holy Family Hospital, Rawalpindi Medical University and Allied Hospitals,FCPS Anesthesia,FCPS Anesthesia,FCPS Anesthesia,Pakistan Atomic Energy Commission General Hospital,Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO2 and cardio-respiratory status. If left untreated, the disease can be fatal.http://dx.doi.org/10.1186/s40545-019-0185-ycyanosismethemoglobinemiaoxidizing agenttissue hypoxia |
| spellingShingle | Najia Mahmood Mutti Ullah Khan Ihtisham U. L. Haq Farhat Afshan Jelani Aayesha Tariq A case of Dapsone Induced Methemoglobinemia Journal of Pharmaceutical Policy and Practice cyanosis methemoglobinemia oxidizing agent tissue hypoxia |
| title | A case of Dapsone Induced Methemoglobinemia |
| title_full | A case of Dapsone Induced Methemoglobinemia |
| title_fullStr | A case of Dapsone Induced Methemoglobinemia |
| title_full_unstemmed | A case of Dapsone Induced Methemoglobinemia |
| title_short | A case of Dapsone Induced Methemoglobinemia |
| title_sort | case of dapsone induced methemoglobinemia |
| topic | cyanosis methemoglobinemia oxidizing agent tissue hypoxia |
| url | http://dx.doi.org/10.1186/s40545-019-0185-y |
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