PAX8 and MECOM are interaction partners driving ovarian cancer
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian t...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22708-w |
| _version_ | 1830145326723366912 |
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| author | Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli |
| author_facet | Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli |
| author_sort | Melusine Bleu |
| collection | DOAJ |
| description | Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis. |
| first_indexed | 2024-12-17T10:22:07Z |
| format | Article |
| id | doaj.art-e459f346777c48fab385e6b2235f6c4c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:22:07Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e459f346777c48fab385e6b2235f6c4c2022-12-21T21:52:47ZengNature PortfolioNature Communications2041-17232021-04-0112111210.1038/s41467-021-22708-wPAX8 and MECOM are interaction partners driving ovarian cancerMelusine Bleu0Fanny Mermet-Meillon1Verena Apfel2Louise Barys3Laura Holzer4Marianne Bachmann Salvy5Rui Lopes6Inês Amorim Monteiro Barbosa7Cecile Delmas8Alexandra Hinniger9Suzanne Chau10Markus Kaufmann11Simon Haenni12Karolin Berneiser13Maria Wahle14Ivana Moravec15Alexandra Vissières16Tania Poetsch17Erik Ahrné18Nathalie Carte19Johannes Voshol20Elisabeth Bechter21Jacques Hamon22Marco Meyerhofer23Dirk Erdmann24Matteo Fischer25Therese Stachyra26Felix Freuler27Sascha Gutmann28César Fernández29Tobias Schmelzle30Ulrike Naumann31Guglielmo Roma32Kate Lawrenson33Cristina Nieto-Oberhuber34Amanda Cobos-Correa35Stephane Ferretti36Dirk Schübeler37Giorgio Giacomo Galli38Disease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchAnalytical Sciences and Imaging, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchCedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer CenterGlobal Discovery Chemistry, Novartis Institutes for Biomedical ResearchChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchDisease area Oncology, Novartis Institutes for Biomedical ResearchFriedrich Miescher Institute for Biomedical Research, University of BaselDisease area Oncology, Novartis Institutes for Biomedical ResearchLineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.https://doi.org/10.1038/s41467-021-22708-w |
| spellingShingle | Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli PAX8 and MECOM are interaction partners driving ovarian cancer Nature Communications |
| title | PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_full | PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_fullStr | PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_full_unstemmed | PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_short | PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_sort | pax8 and mecom are interaction partners driving ovarian cancer |
| url | https://doi.org/10.1038/s41467-021-22708-w |
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