PAX8 and MECOM are interaction partners driving ovarian cancer
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian t...
Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Médium: | Článek |
Jazyk: | English |
Vydáno: |
Nature Portfolio
2021-04-01
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Edice: | Nature Communications |
On-line přístup: | https://doi.org/10.1038/s41467-021-22708-w |