Enhancing Squalene Production in Saccharomyces cerevisiae by Metabolic Engineering and Random Mutagenesis

Enhancing Squalene Production in Saccharomyces cerevisiae by Metabolic Engineering and Random Mutagenesis

Squalene is an important polyunsaturated triterpene with wide applications in the food, cosmetics, and pharmaceutical industries. Currently, the main method for squalene production is extraction from oil-producing plants, but the scale is limited. The microbial fermentation with Saccharomyces cerevi...

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Bibliographic Details
Main Authors: Lu Xia, Yunbin Lv, Song Liu, Shiqin Yu, Weizhu Zeng, Jingwen Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Chemical Engineering
Subjects:
Saccharomyces cerevisiae
promotor substitution
multi-copy site integration
high-throughput screening
β-oxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fceng.2021.790261/full

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