| Summary: | Summary: Promoting facial nerve regeneration is a significant challenge. Aim: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. Method: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. Results: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. Conclusion: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats. Keywords: cyclic amp, histology, facial nerve, rat, nerve regeneration
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