Influence of cyclic AMP on facial nerve regeneration in rats
Summary: Promoting facial nerve regeneration is a significant challenge. Aim: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. Method: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2008-09-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869415313768 |
| _version_ | 1818452020935262208 |
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| author | Andrei Borin Ronaldo Nunes Toledo Paulo Lee Ho José Ricardo Gurgel Testa Oswaldo Laércio Mendonça Cruz Yotaka Fukuda |
| author_facet | Andrei Borin Ronaldo Nunes Toledo Paulo Lee Ho José Ricardo Gurgel Testa Oswaldo Laércio Mendonça Cruz Yotaka Fukuda |
| author_sort | Andrei Borin |
| collection | DOAJ |
| description | Summary: Promoting facial nerve regeneration is a significant challenge. Aim: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. Method: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. Results: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. Conclusion: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats. Keywords: cyclic amp, histology, facial nerve, rat, nerve regeneration |
| first_indexed | 2024-12-14T21:16:27Z |
| format | Article |
| id | doaj.art-e45beaeca1e64309b36811dd45d2710e |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-12-14T21:16:27Z |
| publishDate | 2008-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-e45beaeca1e64309b36811dd45d2710e2022-12-21T22:47:02ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942008-09-01745675683Influence of cyclic AMP on facial nerve regeneration in ratsAndrei Borin0Ronaldo Nunes Toledo1Paulo Lee Ho2José Ricardo Gurgel Testa3Oswaldo Laércio Mendonça Cruz4Yotaka Fukuda5Master’s degree in otorhinolaryngology; doctoral student; Address for correspondence: Andrei Borin Rua Loefgreen 1587 apto 152 Sao Paulo SP 04040-032Biologist and doctorate in biochemistry; researcher at the Centro de Biotecnologia, Instituto ButantanDoctorate in otorhinolaryngology, adjunct professor, otorhinolaryngology discipline, UNIFESP/EPMLivre-docente (habilitation) professor, affiliated professor, otorhinolaryngology discipline, UNIFESP/EPMLivre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao PauloLivre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao PauloSummary: Promoting facial nerve regeneration is a significant challenge. Aim: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. Method: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. Results: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. Conclusion: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats. Keywords: cyclic amp, histology, facial nerve, rat, nerve regenerationhttp://www.sciencedirect.com/science/article/pii/S1808869415313768 |
| spellingShingle | Andrei Borin Ronaldo Nunes Toledo Paulo Lee Ho José Ricardo Gurgel Testa Oswaldo Laércio Mendonça Cruz Yotaka Fukuda Influence of cyclic AMP on facial nerve regeneration in rats Brazilian Journal of Otorhinolaryngology |
| title | Influence of cyclic AMP on facial nerve regeneration in rats |
| title_full | Influence of cyclic AMP on facial nerve regeneration in rats |
| title_fullStr | Influence of cyclic AMP on facial nerve regeneration in rats |
| title_full_unstemmed | Influence of cyclic AMP on facial nerve regeneration in rats |
| title_short | Influence of cyclic AMP on facial nerve regeneration in rats |
| title_sort | influence of cyclic amp on facial nerve regeneration in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1808869415313768 |
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