Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches

Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches

In addition to deoxynivalenol (DON), acetylated derivatives, i.e., 3-acetyl and 15-acetyldexynivalenol (or 3/15ADON), are present in cereals leading to exposure to these mycotoxins. Animal and human studies suggest that 3/15ADON are converted into DON after their ingestion through hydrolysis of the...

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Bibliographic Details
Main Authors: El Hassan Ajandouz, Stéphane Berdah, Vincent Moutardier, Thierry Bege, David Jérémie Birnbaum, Josette Perrier, Eric Di Pasquale, Marc Maresca
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Toxins
Subjects:
mycotoxin
deoxynivalenol
3-acetyldeoxynivalenol
15-acetyldeoxynivalenol
carboxylesterase
human explants
Caco-2
T84
HepG2
A498
Online Access:http://www.mdpi.com/2072-6651/8/8/232

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