Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients
Several clinical trials in patients with chronic disease have found that active vitamin D usage lowers pro-inflammatory cytokines. The aim of this study was evaluate whether supplementation of cholecalciferol in peritoneal dialysis patients with vitamin D deficiency would lead any chance in the pro...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2017-09-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=247859 |
| _version_ | 1797327659787616256 |
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| author | Ibrahim Orman Hulya Taskapan Mehmet Cagatay Taskapan Fatma Ozyalin Irfan Kuku |
| author_facet | Ibrahim Orman Hulya Taskapan Mehmet Cagatay Taskapan Fatma Ozyalin Irfan Kuku |
| author_sort | Ibrahim Orman |
| collection | DOAJ |
| description | Several clinical trials in patients with chronic disease have found that active vitamin D usage lowers pro-inflammatory cytokines. The aim of this study was evaluate whether supplementation of cholecalciferol in peritoneal dialysis patients with vitamin D deficiency would lead any chance in the pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10, and pentraxin 3 and peripheral blood mononuclear cell subpopulations (CD3, CD4, CD8, CD45)and CD4/CD8 ratio. We analyzed fasting blood samples from 31 continuous peritoneal dialysis patients (14 males, 16 females, mean age 48,6±14,8 yrs) for serum 25-hydroxyvitamin D [25(OH)D)] and specific plasma cytokine concentrations (interferon-gamma [IFN-γ], interleukin [IL]-4, and IL-10), pentraxine 3, CD3, CD4, CD8 and CD45 before and after cholecalciferol replacement. Before and after cholecalciferol replacement mean 25 (OH) level was 6,1±2,1 ng/dL and 39,7±10,9 ng/dL respectively (p [Med-Science 2017; 6(3.000): 393-7] |
| first_indexed | 2024-03-08T06:41:40Z |
| format | Article |
| id | doaj.art-e462937fc5a642c08f9bf373d3fb9001 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:41:40Z |
| publishDate | 2017-09-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-e462937fc5a642c08f9bf373d3fb90012024-02-03T08:38:23ZengSociety of Turaz BilimMedicine Science2147-06342017-09-0163393710.5455/medscience.2016.05.8575247859Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis PatientsIbrahim Orman0Hulya Taskapan1Mehmet Cagatay Taskapan2Fatma Ozyalin3Irfan Kuku4Malatya state HospitalInonu University Medical Faculty Nephrology DepartmentInonu University Medical Faculty Biochemistry DepartmentInonu University Medical Faculty Biochemistry DepartmentInonu University Medical Faculty Hematology DepartmentSeveral clinical trials in patients with chronic disease have found that active vitamin D usage lowers pro-inflammatory cytokines. The aim of this study was evaluate whether supplementation of cholecalciferol in peritoneal dialysis patients with vitamin D deficiency would lead any chance in the pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10, and pentraxin 3 and peripheral blood mononuclear cell subpopulations (CD3, CD4, CD8, CD45)and CD4/CD8 ratio. We analyzed fasting blood samples from 31 continuous peritoneal dialysis patients (14 males, 16 females, mean age 48,6±14,8 yrs) for serum 25-hydroxyvitamin D [25(OH)D)] and specific plasma cytokine concentrations (interferon-gamma [IFN-γ], interleukin [IL]-4, and IL-10), pentraxine 3, CD3, CD4, CD8 and CD45 before and after cholecalciferol replacement. Before and after cholecalciferol replacement mean 25 (OH) level was 6,1±2,1 ng/dL and 39,7±10,9 ng/dL respectively (p [Med-Science 2017; 6(3.000): 393-7]http://www.ejmanager.com/fulltextpdf.php?mno=247859DialysisVitamin Dpro-inflammatory cytokinesanti-inflammatory cytokinesperipheral blood mononuclear cell subpopulations |
| spellingShingle | Ibrahim Orman Hulya Taskapan Mehmet Cagatay Taskapan Fatma Ozyalin Irfan Kuku Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients Medicine Science Dialysis Vitamin D pro-inflammatory cytokines anti-inflammatory cytokines peripheral blood mononuclear cell subpopulations |
| title | Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients |
| title_full | Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients |
| title_fullStr | Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients |
| title_full_unstemmed | Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients |
| title_short | Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients |
| title_sort | vitamin d and pro inflammatory cytokine ifn 947 and the anti inflammatory cytokines il 4 and il 10 in peritoneal dialysis patients |
| topic | Dialysis Vitamin D pro-inflammatory cytokines anti-inflammatory cytokines peripheral blood mononuclear cell subpopulations |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=247859 |
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