Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury
BackgroundThe geriatric nutritional risk index (GNRI) is a simple index for evaluating the nutrition status of elderly patients. Many investigations have demonstrated that this index is associated with the prognosis of several diseases. This study aims to identify the relationship between the GNRI a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1131085/full |
| _version_ | 1797852948984758272 |
|---|---|
| author | Bingcheng Zhu Yunwei Ou Xufei Guo Weiming Liu Weiming Liu Weiming Liu Liang Wu |
| author_facet | Bingcheng Zhu Yunwei Ou Xufei Guo Weiming Liu Weiming Liu Weiming Liu Liang Wu |
| author_sort | Bingcheng Zhu |
| collection | DOAJ |
| description | BackgroundThe geriatric nutritional risk index (GNRI) is a simple index for evaluating the nutrition status of elderly patients. Many investigations have demonstrated that this index is associated with the prognosis of several diseases. This study aims to identify the relationship between the GNRI and recovery in elderly mild traumatic brain injury (mTBI) patients.MethodsA total of 228 mTBI patients older than 65 years were included in this study. mTBI was defined as an injury to the brain with a loss of consciousness of 30 min or less, a duration of posttraumatic amnesia of <24 h, and an admission Glasgow Coma Scale (GCS) score of 13–15. The Glasgow Outcome Scale Extended (GOSE), an outcome scale assessing functional independence, work, social activities, and personal relationships, was applied to assess the recovery of the patients. The clinical outcome was divided into complete recovery (GOSE = 8) and incomplete recovery (GOSE ≤ 7) at 6 months after the injury. Multivariate logistic regression was applied to evaluate the association between the GNRI and recovery of elderly mTBI patients, with adjustment for age, sex, hypertension, diabetes, and other important factors.ResultsThe receiver operating curve (ROC) analysis demonstrated that the cutoff value of GNRI was 97.85, and the area under the curve (AUC) was 0.860. Compared to the patients with a high GNRI, the patients with a low GNRI were older, had a higher prevalence of anemia, acute subdural hematoma, and subarachnoid hemorrhage, had a higher age-adjusted Charlson Comorbidity Index value, and had lower levels of albumin, lymphocytes, and hemoglobin. Multivariable analysis showed that high GNRI was associated with a lower risk of 6-month incomplete recovery (OR, 0.770, 95% CI: 0.709–0.837, p < 0.001).ConclusionThe GNRI has utility as part of the objective risk assessment of incomplete 6-month functional recovery in elderly patients with mTBI. |
| first_indexed | 2024-04-09T19:42:37Z |
| format | Article |
| id | doaj.art-e4656ffaebca49ae9e8077e786622d96 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T19:42:37Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e4656ffaebca49ae9e8077e786622d962023-04-04T05:02:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11310851131085Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injuryBingcheng Zhu0Yunwei Ou1Xufei Guo2Weiming Liu3Weiming Liu4Weiming Liu5Liang Wu6Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaNeurological Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBackgroundThe geriatric nutritional risk index (GNRI) is a simple index for evaluating the nutrition status of elderly patients. Many investigations have demonstrated that this index is associated with the prognosis of several diseases. This study aims to identify the relationship between the GNRI and recovery in elderly mild traumatic brain injury (mTBI) patients.MethodsA total of 228 mTBI patients older than 65 years were included in this study. mTBI was defined as an injury to the brain with a loss of consciousness of 30 min or less, a duration of posttraumatic amnesia of <24 h, and an admission Glasgow Coma Scale (GCS) score of 13–15. The Glasgow Outcome Scale Extended (GOSE), an outcome scale assessing functional independence, work, social activities, and personal relationships, was applied to assess the recovery of the patients. The clinical outcome was divided into complete recovery (GOSE = 8) and incomplete recovery (GOSE ≤ 7) at 6 months after the injury. Multivariate logistic regression was applied to evaluate the association between the GNRI and recovery of elderly mTBI patients, with adjustment for age, sex, hypertension, diabetes, and other important factors.ResultsThe receiver operating curve (ROC) analysis demonstrated that the cutoff value of GNRI was 97.85, and the area under the curve (AUC) was 0.860. Compared to the patients with a high GNRI, the patients with a low GNRI were older, had a higher prevalence of anemia, acute subdural hematoma, and subarachnoid hemorrhage, had a higher age-adjusted Charlson Comorbidity Index value, and had lower levels of albumin, lymphocytes, and hemoglobin. Multivariable analysis showed that high GNRI was associated with a lower risk of 6-month incomplete recovery (OR, 0.770, 95% CI: 0.709–0.837, p < 0.001).ConclusionThe GNRI has utility as part of the objective risk assessment of incomplete 6-month functional recovery in elderly patients with mTBI.https://www.frontiersin.org/articles/10.3389/fneur.2023.1131085/fullmild traumatic brain injurygeriatric nutritional risk indexnutritionelderlyprognosisnutritional supplement |
| spellingShingle | Bingcheng Zhu Yunwei Ou Xufei Guo Weiming Liu Weiming Liu Weiming Liu Liang Wu Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury Frontiers in Neurology mild traumatic brain injury geriatric nutritional risk index nutrition elderly prognosis nutritional supplement |
| title | Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| title_full | Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| title_fullStr | Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| title_full_unstemmed | Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| title_short | Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| title_sort | poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury |
| topic | mild traumatic brain injury geriatric nutritional risk index nutrition elderly prognosis nutritional supplement |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1131085/full |
| work_keys_str_mv | AT bingchengzhu poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT yunweiou poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT xufeiguo poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT weimingliu poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT weimingliu poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT weimingliu poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury AT liangwu poornutritionalstatusisassociatedwithincompletefunctionalrecoveryinelderlypatientswithmildtraumaticbraininjury |