Resting State Glucose Utilization and Adult Reading Test Performance
Adult reading tests (ART) have been widely used in both research and clinical settings as a measure of premorbid cognitive abilities or cognitive reserve. However, the neural substrates underlying ART performance are largely unknown. Furthermore, it has not yet been examined whether the neural subst...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2020.00048/full |
| _version_ | 1818135280665755648 |
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| author | Younghwa Lee Dahyun Yi Eun Hyun Seo Ji Young Han Haejung Joung Min Soo Byun Jun Ho Lee Jongho Jun Dong Young Lee Dong Young Lee Dong Young Lee Dong Young Lee |
| author_facet | Younghwa Lee Dahyun Yi Eun Hyun Seo Ji Young Han Haejung Joung Min Soo Byun Jun Ho Lee Jongho Jun Dong Young Lee Dong Young Lee Dong Young Lee Dong Young Lee |
| author_sort | Younghwa Lee |
| collection | DOAJ |
| description | Adult reading tests (ART) have been widely used in both research and clinical settings as a measure of premorbid cognitive abilities or cognitive reserve. However, the neural substrates underlying ART performance are largely unknown. Furthermore, it has not yet been examined whether the neural substrates of ART performance reflect the cortical regions associated with premorbid intelligence or cognitive reserve. The aim of the study is to identify the functional neural correlates of ART performance using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in the cognitively normal (CN) middle- and old-aged adults. Voxel-wise analyses revealed positive correlations between glucose metabolism and ART performance in the frontal and primary somatosensory regions, more specifically the lateral frontal cortex, anterior cingulate cortex and postcentral gyrus (PCG). When conducted again only for amyloid-β (Aβ)-negative individuals, the voxel-wise analysis showed significant correlations in broader areas of the frontal and primary somatosensory regions. This is the first neuroimaging study to directly demonstrate the cerebral resting-state glucose utilization associated with ART performance. Our findings provide important evidence at the neural level that ART predicts premorbid general intelligence and cognitive reserve, as brain areas that showed significant correlations with ART performance correspond to regions that have been associated with general intelligence and cognitive reserve. |
| first_indexed | 2024-12-11T09:22:00Z |
| format | Article |
| id | doaj.art-e4659fb5488045da88b44422ea87a5b3 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T09:22:00Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e4659fb5488045da88b44422ea87a5b32022-12-22T01:13:14ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-03-011210.3389/fnagi.2020.00048510662Resting State Glucose Utilization and Adult Reading Test PerformanceYounghwa Lee0Dahyun Yi1Eun Hyun Seo2Ji Young Han3Haejung Joung4Min Soo Byun5Jun Ho Lee6Jongho Jun7Dong Young Lee8Dong Young Lee9Dong Young Lee10Dong Young Lee11Interdisciplinary Program of Cognitive Science, Seoul National University, Seoul, South KoreaInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, South KoreaPremedical Science, College of Medicine, Chosun University, Gwangju, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaInterdisciplinary Program of Cognitive Science, Seoul National University, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Sungnam, South KoreaDepartment of Geriatric Psychiatry, National Center for Mental Health, Seoul, South KoreaDepartment of Linguistics, Seoul National University, Seoul, South KoreaInterdisciplinary Program of Cognitive Science, Seoul National University, Seoul, South KoreaInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, South KoreaAdult reading tests (ART) have been widely used in both research and clinical settings as a measure of premorbid cognitive abilities or cognitive reserve. However, the neural substrates underlying ART performance are largely unknown. Furthermore, it has not yet been examined whether the neural substrates of ART performance reflect the cortical regions associated with premorbid intelligence or cognitive reserve. The aim of the study is to identify the functional neural correlates of ART performance using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in the cognitively normal (CN) middle- and old-aged adults. Voxel-wise analyses revealed positive correlations between glucose metabolism and ART performance in the frontal and primary somatosensory regions, more specifically the lateral frontal cortex, anterior cingulate cortex and postcentral gyrus (PCG). When conducted again only for amyloid-β (Aβ)-negative individuals, the voxel-wise analysis showed significant correlations in broader areas of the frontal and primary somatosensory regions. This is the first neuroimaging study to directly demonstrate the cerebral resting-state glucose utilization associated with ART performance. Our findings provide important evidence at the neural level that ART predicts premorbid general intelligence and cognitive reserve, as brain areas that showed significant correlations with ART performance correspond to regions that have been associated with general intelligence and cognitive reserve.https://www.frontiersin.org/article/10.3389/fnagi.2020.00048/fulladult reading testcerebral glucose metabolismcognitive reservebeta-amyloidcognitively normal adults |
| spellingShingle | Younghwa Lee Dahyun Yi Eun Hyun Seo Ji Young Han Haejung Joung Min Soo Byun Jun Ho Lee Jongho Jun Dong Young Lee Dong Young Lee Dong Young Lee Dong Young Lee Resting State Glucose Utilization and Adult Reading Test Performance Frontiers in Aging Neuroscience adult reading test cerebral glucose metabolism cognitive reserve beta-amyloid cognitively normal adults |
| title | Resting State Glucose Utilization and Adult Reading Test Performance |
| title_full | Resting State Glucose Utilization and Adult Reading Test Performance |
| title_fullStr | Resting State Glucose Utilization and Adult Reading Test Performance |
| title_full_unstemmed | Resting State Glucose Utilization and Adult Reading Test Performance |
| title_short | Resting State Glucose Utilization and Adult Reading Test Performance |
| title_sort | resting state glucose utilization and adult reading test performance |
| topic | adult reading test cerebral glucose metabolism cognitive reserve beta-amyloid cognitively normal adults |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2020.00048/full |
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