Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i>
In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality bas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7323 |
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| author | Nkwachukwu Oziamara Okoro Arome Solomon Odiba Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Guiyan Liao Wenxia Fang Cheng Jin Bin Wang |
| author_facet | Nkwachukwu Oziamara Okoro Arome Solomon Odiba Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Guiyan Liao Wenxia Fang Cheng Jin Bin Wang |
| author_sort | Nkwachukwu Oziamara Okoro |
| collection | DOAJ |
| description | In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality based on their broad potentials as antioxidant, anti-microbial, anti-carcinogenic, anti-inflammatory, neuroprotective, and anti-aging effects, amongst others. For the past decade and half, efforts to discover bioactive phytochemicals both in pure and crude forms have been intensified using the <i>Caenorhabditis elegans</i> aging model, in which various metabolic pathways in humans are highly conserved. In this review, we summarized the aging and longevity pathways that are common to <i>C. elegans</i> and humans and collated some of the bioactive phytochemicals with health benefits and lifespan extending effects that have been studied in <i>C. elegans</i>. This simple animal model is not only a perfect system for discovering bioactive compounds but is also a research shortcut for elucidating the amelioration mechanisms of aging risk factors and associated diseases. |
| first_indexed | 2024-03-10T04:47:52Z |
| format | Article |
| id | doaj.art-e465b577fd8844f9ba1f01f87e83f368 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:47:52Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e465b577fd8844f9ba1f01f87e83f3682023-11-23T02:50:48ZengMDPI AGMolecules1420-30492021-12-012623732310.3390/molecules26237323Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i>Nkwachukwu Oziamara Okoro0Arome Solomon Odiba1Patience Ogoamaka Osadebe2Edwin Ogechukwu Omeje3Guiyan Liao4Wenxia Fang5Cheng Jin6Bin Wang7National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, ChinaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, ChinaDepartment of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, NigeriaState Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, ChinaCollege of Life Science and Technology, Guangxi University, Nanning 530007, ChinaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, ChinaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, ChinaIn the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality based on their broad potentials as antioxidant, anti-microbial, anti-carcinogenic, anti-inflammatory, neuroprotective, and anti-aging effects, amongst others. For the past decade and half, efforts to discover bioactive phytochemicals both in pure and crude forms have been intensified using the <i>Caenorhabditis elegans</i> aging model, in which various metabolic pathways in humans are highly conserved. In this review, we summarized the aging and longevity pathways that are common to <i>C. elegans</i> and humans and collated some of the bioactive phytochemicals with health benefits and lifespan extending effects that have been studied in <i>C. elegans</i>. This simple animal model is not only a perfect system for discovering bioactive compounds but is also a research shortcut for elucidating the amelioration mechanisms of aging risk factors and associated diseases.https://www.mdpi.com/1420-3049/26/23/7323agingbioactive compounds<i>Caenorhabditis elegans</i>longevity pathwayslifespan |
| spellingShingle | Nkwachukwu Oziamara Okoro Arome Solomon Odiba Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Guiyan Liao Wenxia Fang Cheng Jin Bin Wang Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> Molecules aging bioactive compounds <i>Caenorhabditis elegans</i> longevity pathways lifespan |
| title | Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> |
| title_full | Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> |
| title_fullStr | Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> |
| title_short | Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in <i>Caenorhabditis elegans</i> |
| title_sort | bioactive phytochemicals with anti aging and lifespan extending potentials in i caenorhabditis elegans i |
| topic | aging bioactive compounds <i>Caenorhabditis elegans</i> longevity pathways lifespan |
| url | https://www.mdpi.com/1420-3049/26/23/7323 |
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