A free customizable tool for easy integration of microfluidics and smartphones
Abstract The integration of smartphones and microfluidics is nowadays the best possible route to achieve effective point-of-need testing (PONT), a concept increasingly demanded in the fields of human health, agriculture, food safety, and environmental monitoring. Nevertheless, efforts are still requ...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13099-z |
| _version_ | 1818239183200714752 |
|---|---|
| author | Federico Schaumburg Juan P. Vidocevich Gabriel S. Gerlero Nazarena Pujato Joana Macagno Pablo A. Kler Claudio L. A. Berli |
| author_facet | Federico Schaumburg Juan P. Vidocevich Gabriel S. Gerlero Nazarena Pujato Joana Macagno Pablo A. Kler Claudio L. A. Berli |
| author_sort | Federico Schaumburg |
| collection | DOAJ |
| description | Abstract The integration of smartphones and microfluidics is nowadays the best possible route to achieve effective point-of-need testing (PONT), a concept increasingly demanded in the fields of human health, agriculture, food safety, and environmental monitoring. Nevertheless, efforts are still required to integrally seize all the advantages of smartphones, as well as to share the developments in easily adoptable formats. For this purpose, here we present the free platform appuente that was designed for the easy integration of microfluidic chips, smartphones, and the cloud. It includes a mobile app for end users, which provides chip identification and tracking, guidance and control, processing, smart-imaging, result reporting and cloud and Internet of Things (IoT) integration. The platform also includes a web app for PONT developers, to easily customize their mobile apps and manage the data of administered tests. Three application examples were used to validate appuente: a dummy grayscale detector that mimics quantitative colorimetric tests, a root elongation assay for pesticide toxicity assessment, and a lateral flow immunoassay for leptospirosis detection. The platform openly offers fast prototyping of smartphone apps to the wide community of lab-on-a-chip developers, and also serves as a friendly framework for new techniques, IoT integration and further capabilities. Exploiting these advantages will certainly help to enlarge the use of PONT with real-time connectivity in the near future. |
| first_indexed | 2024-12-12T12:53:30Z |
| format | Article |
| id | doaj.art-e466d3a86f064b6d9f620548f6d5c967 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T12:53:30Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e466d3a86f064b6d9f620548f6d5c9672022-12-22T00:23:57ZengNature PortfolioScientific Reports2045-23222022-05-0112111210.1038/s41598-022-13099-zA free customizable tool for easy integration of microfluidics and smartphonesFederico Schaumburg0Juan P. Vidocevich1Gabriel S. Gerlero2Nazarena Pujato3Joana Macagno4Pablo A. Kler5Claudio L. A. Berli6Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET)Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET)Centro de Investigación de Métodos Computacionales (CIMEC, UNL-CONICET)Laboratorio de Tecnología Inmunológica (FBCB, UNL)Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET)Centro de Investigación de Métodos Computacionales (CIMEC, UNL-CONICET)Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET)Abstract The integration of smartphones and microfluidics is nowadays the best possible route to achieve effective point-of-need testing (PONT), a concept increasingly demanded in the fields of human health, agriculture, food safety, and environmental monitoring. Nevertheless, efforts are still required to integrally seize all the advantages of smartphones, as well as to share the developments in easily adoptable formats. For this purpose, here we present the free platform appuente that was designed for the easy integration of microfluidic chips, smartphones, and the cloud. It includes a mobile app for end users, which provides chip identification and tracking, guidance and control, processing, smart-imaging, result reporting and cloud and Internet of Things (IoT) integration. The platform also includes a web app for PONT developers, to easily customize their mobile apps and manage the data of administered tests. Three application examples were used to validate appuente: a dummy grayscale detector that mimics quantitative colorimetric tests, a root elongation assay for pesticide toxicity assessment, and a lateral flow immunoassay for leptospirosis detection. The platform openly offers fast prototyping of smartphone apps to the wide community of lab-on-a-chip developers, and also serves as a friendly framework for new techniques, IoT integration and further capabilities. Exploiting these advantages will certainly help to enlarge the use of PONT with real-time connectivity in the near future.https://doi.org/10.1038/s41598-022-13099-z |
| spellingShingle | Federico Schaumburg Juan P. Vidocevich Gabriel S. Gerlero Nazarena Pujato Joana Macagno Pablo A. Kler Claudio L. A. Berli A free customizable tool for easy integration of microfluidics and smartphones Scientific Reports |
| title | A free customizable tool for easy integration of microfluidics and smartphones |
| title_full | A free customizable tool for easy integration of microfluidics and smartphones |
| title_fullStr | A free customizable tool for easy integration of microfluidics and smartphones |
| title_full_unstemmed | A free customizable tool for easy integration of microfluidics and smartphones |
| title_short | A free customizable tool for easy integration of microfluidics and smartphones |
| title_sort | free customizable tool for easy integration of microfluidics and smartphones |
| url | https://doi.org/10.1038/s41598-022-13099-z |
| work_keys_str_mv | AT federicoschaumburg afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT juanpvidocevich afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT gabrielsgerlero afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT nazarenapujato afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT joanamacagno afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT pabloakler afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT claudiolaberli afreecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT federicoschaumburg freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT juanpvidocevich freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT gabrielsgerlero freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT nazarenapujato freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT joanamacagno freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT pabloakler freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones AT claudiolaberli freecustomizabletoolforeasyintegrationofmicrofluidicsandsmartphones |