Stem Cell Therapy in Stargardt Disease: A Systematic Review
Abstract This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, includ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2023-07-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v18i3.13780 |
| _version_ | 1797743344445554688 |
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| author | Atousa Moghadam Fard Reza Mirshahi Masood Naseripour Khalil Ghasemi Falavarjani |
| author_facet | Atousa Moghadam Fard Reza Mirshahi Masood Naseripour Khalil Ghasemi Falavarjani |
| author_sort | Atousa Moghadam Fard |
| collection | DOAJ |
| description | Abstract This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type. |
| first_indexed | 2024-03-12T14:54:08Z |
| format | Article |
| id | doaj.art-e4673a5e18ce40d39080b03dcf2c6393 |
| institution | Directory Open Access Journal |
| issn | 2008-2010 2008-322X |
| language | English |
| last_indexed | 2024-03-12T14:54:08Z |
| publishDate | 2023-07-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-e4673a5e18ce40d39080b03dcf2c63932023-08-15T05:44:01ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2023-07-0118331832710.18502/jovr.v18i3.13780jovr.v18i3.13780Stem Cell Therapy in Stargardt Disease: A Systematic ReviewAtousa Moghadam Fard0Reza Mirshahi1Masood Naseripour2Khalil Ghasemi Falavarjani3 Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, IranAbstract This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type.https://doi.org/10.18502/jovr.v18i3.13780juvenile-onset macular degenerationjuvenile-onset macular dystrophystargardt diseasestem cellstem cell therapy |
| spellingShingle | Atousa Moghadam Fard Reza Mirshahi Masood Naseripour Khalil Ghasemi Falavarjani Stem Cell Therapy in Stargardt Disease: A Systematic Review Journal of Ophthalmic & Vision Research juvenile-onset macular degeneration juvenile-onset macular dystrophy stargardt disease stem cell stem cell therapy |
| title | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
| title_full | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
| title_fullStr | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
| title_full_unstemmed | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
| title_short | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
| title_sort | stem cell therapy in stargardt disease a systematic review |
| topic | juvenile-onset macular degeneration juvenile-onset macular dystrophy stargardt disease stem cell stem cell therapy |
| url | https://doi.org/10.18502/jovr.v18i3.13780 |
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